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Extracts and fractions of Inonotus obliquus (Chaga in Russia) have been known to have various biological activities,
including antimutagenic, anticancer, antioxidative, and immunostimulating effects. This study was performed to confirm
anticancer effect of 10% superfine Chaga mushroom processed by nano-mill technology on C57BL/6 mice. Chaga particles
belonged in the size of 1 μm was about 40% after nanomill processing according to the volume distribution. As the
result of subcutaneous injection of B16BL6 melanoma cells to the mice, the tumor volume (p<0.001) and tumor weight
(p<0.01) was significantly decreased in the experimental (NCh) group as compared with control (C) group and the tumor
growth inhibitory rate was 29.2%. On examination of survival rate after intraperitoneal injection of B16BL6 melanoma
cells, the mean survival time per a mouse was 17.7 and 26.0 days in C and NCh group respectively. The survival rate of
NCh group was 40% when that of C group was 0% at the 35th day. On the result of examination to confirm histological
toxicity by Chaga superfine particles, both groups did not show any morphological and pathological changes in the small
and large intestine under the light microscope. These results suggest that feeding of superfine Chaga produced by nanomill
technique has a tumor growth inhibitory effect in vivo.
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참고문헌 (23)
참고문헌 신청
Babitskaia VG / 2000 / Melanin complex of the fungus Inonotus obliquus / Prikl Biokhim Mikrobiol 36 (4) : 439 ~ 444
Cui Y / 2005 / Antioxidant effect of Inonotus obliquus / J Ethnopharmacol 96 : 79 ~ 85
Federico A / 2007 / Chronic inflammation and oxidative stress in human carcinogenesis / Int J Cancer 121 (11) : 2381 ~ 2386
Florence AT / 1995 / Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence / J Drug Target 3 (1) : 65 ~ 70
Jarosz A / 1990 / Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells / Acta Biochim Pol 37 (1) : 149 ~ 151
Cui Y / 2005 / Antioxidant effect of Inonotus obliquus / J Ethnopharmacol 96 : 79 ~ 85
Federico A / 2007 / Chronic inflammation and oxidative stress in human carcinogenesis / Int J Cancer 121 (11) : 2381 ~ 2386
Florence AT / 1995 / Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence / J Drug Target 3 (1) : 65 ~ 70
Jarosz A / 1990 / Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells / Acta Biochim Pol 37 (1) : 149 ~ 151
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