지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The protective effect of metformin against breast cancer is inconclusive. Objective: To evaluate the effect of metformin on breast cancer risk and mortality in patients with type 2 diabetes. Method: A comprehensive literature search was performed for pertinent articles published prior to June 30, 2014, using PubMed and EMBASE. Study heterogeneity was estimated with I2 statistic.
The data from the included studies were pooled and weighted by random-effects model. The quality of each included study was assessed on the basis of the 9-star Newcastle-Ottawa Scale and publication bias was evaluated by visual inspection of a funnel plot. Results: Ten studies were included in the meta-analysis of the association of metformin and breast cancer risk. By synthesizing the data from the studies, the pooled odds ratio (OR) was 0.72 (95% CI: 0.59, 0.87) (p = 0.0005). Three cohort studies were included for meta-analysis of the association between metformin and breast cancer-related mortality. Metformin was associated with a significant decrease in mortality (Risk ratio: 0.68; 95% CI: 0.51, 0.90, p = 0.007). Conclusion: The present metaanalysis suggests that metformin appears to be associated with a lower risk of breast cancer incidence and mortality in patients with type 2 diabetes.
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참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] -
American Diabetes Association. / 2008 / Diagnosis and Classification of Diabetes Mellitus / Diabetes Care 31 (Suppl 1) : S55 ~ S60
Arcidiacono B. / 2012 / Insulin resistance and cancer risk : an overview of the pathogenetic mechanisms / Exp Diabetes Res 2012 : 789174 ~
Baron JA. / 2001 / Metabolic disorders and breast cancer risk(United States) / Cancer Causes Control 12 : 875 ~ 880
Bayraktar S. / 2012 / Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer / Cancer 118 : 1202 ~ 1211
American Diabetes Association. / 2008 / Diagnosis and Classification of Diabetes Mellitus / Diabetes Care 31 (Suppl 1) : S55 ~ S60
Arcidiacono B. / 2012 / Insulin resistance and cancer risk : an overview of the pathogenetic mechanisms / Exp Diabetes Res 2012 : 789174 ~
Baron JA. / 2001 / Metabolic disorders and breast cancer risk(United States) / Cancer Causes Control 12 : 875 ~ 880
Bayraktar S. / 2012 / Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer / Cancer 118 : 1202 ~ 1211
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