지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: The established theory that breast density is an independent predictor of breast cancer risk is based on studies targeting white women in the West. More Asian women than Western women have dense breasts, but the incidence of breast cancer is lower among Asian women. This meta-analysis investigated the association between breast density in mammography and breast cancer risk in Asian women.
Methods: PubMed and Scopus were searched, and the final date of publication was set as December 31, 2015. The effect size in each article was calculated using the interval-collapse method. Summary effect sizes (sESs) and 95% confidence intervals (CIs) were calculated by conducting a meta-analysis applying a random effect model. To investigate the dose-response relationship, random effect dose-response meta-regression (RE-DRMR) was conducted.
Results: Six analytical epidemiology studies in total were selected, including one cohort study and five case-control studies. A total of 17 datasets were constructed by type of breast density index and menopausal status. In analyzing the subgroups of premenopausal vs. postmenopausal women, the percent density (PD) index was confirmed to be associated with a significantly elevated risk for breast cancer (sES, 2.21; 95% CI, 1.52 to 3.21; I2=50.0%). The RE-DRMR results showed that the risk of breast cancer increased 1.73 times for each 25% increase in PD in postmenopausal women (95% CI, 1.20 to 2.47).
Conclusions: In Asian women, breast cancer risk increased with breast density measured using the PD index, regardless of menopausal status. We propose the further development of a breast cancer risk prediction model based on the application of PD in Asian women.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65(2):87~108
Pettersson A / 2011 / Nondense mammographic area and risk of breast cancer / Breast Cancer Res 13(5):R100
Martin LJ / 2008 / Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence / Breast Cancer Res 10(1):201
Boyd NF / 2011 / Mammographic density and breast cancer risk: current understanding and future prospects / Breast Cancer Res 13(6):223
Saftlas AF / 1987 / Mammographic parenchymal patterns and breast cancer risk / Epidemiol Rev 9:146~174
Pettersson A / 2011 / Nondense mammographic area and risk of breast cancer / Breast Cancer Res 13(5):R100
Martin LJ / 2008 / Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence / Breast Cancer Res 10(1):201
Boyd NF / 2011 / Mammographic density and breast cancer risk: current understanding and future prospects / Breast Cancer Res 13(6):223
Saftlas AF / 1987 / Mammographic parenchymal patterns and breast cancer risk / Epidemiol Rev 9:146~174
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