지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective: To develop a population pharmacokinetics (PK)/pharmacodynamics (PD) model for alcohol in healthy volunteers and toelucidate individual characteristics to affects alcohol’s PK or PD including dissolved oxygen. Methods: Following multiple intakes oftotal 540 mL alcohol (19.42 v/v%) to healthy volunteer, blood alcohol concentration was measured using a Breathe alcohol analyser(Lion SD-400 Alcolmeter®). A sequential population PK/PD modeling was performed using NONMEM (ver 7.3). Results: Eighteenhealthy volunteer were included in the study. PK model of alcohol was well explained by one-compartment model with first-orderabsorption and Michaelis-Menten elimination kinetics. Ka, V/F, Vmax, Km is 8.1 hr-1, 73.7 L, 9.65 g/hr, 0.041 g/L, respectively.
Covariate analysis revealed that gender significantly influenced Vmax (Male vs Female, 9.65 g/hr vs 7.38 g/hr). PD model oftemporary systolic blood pressure decreasing effect of alcohol was explained by biophase model with inhibitory Emax model. Ke0,Imax, E0, IC50 were 0.23 hr-1, 44.9 mmHg, 138 mmHg, 0.693 g/L, respectively. Conclusion: Model evaluation results suggested thatthis PK/PD model was robust and has good precision.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abe H / 1994 / Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients / Circulation 89 (6) : 2626 ~ 2633
Arthur IC / 2012 / Alcohol metabolism / Clin Liver Dis 16 (4) : 667 ~ 685
Baek IH / 2010 / Influence of dissolved oxygen concentration on the pharmacokinetics of alcohol / Alcoholism Clin Exp Res 34 (5) : 834 ~ 839
Baraona E / 2001 / Gender differences in pharmacokinetics of alcohol / Alcohol Clin Exp Res 25 (4) : 502 ~ 507
Jonsson EN / 1998 / Automated covariate model building within NONMEM / Pharm Res 15 (9) : 1463 ~ 1468
Arthur IC / 2012 / Alcohol metabolism / Clin Liver Dis 16 (4) : 667 ~ 685
Baek IH / 2010 / Influence of dissolved oxygen concentration on the pharmacokinetics of alcohol / Alcoholism Clin Exp Res 34 (5) : 834 ~ 839
Baraona E / 2001 / Gender differences in pharmacokinetics of alcohol / Alcohol Clin Exp Res 25 (4) : 502 ~ 507
Jonsson EN / 1998 / Automated covariate model building within NONMEM / Pharm Res 15 (9) : 1463 ~ 1468
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