지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The preventive effect of Salvia miltiorrhiza extracts (SM) with or without high molecular weight soluble kitosan (K) on
the progress of bone loss induced by ovariectomized (OVX) was studied in rats. From light microscopic analyses in
histochemistry data, trabecular bone area in OVX rats was significantly decreased compared with that in sham rats. The
decrease was regulated by administration of SM and especially the combination of SM and K (SM + K) for 7 weeks.
In addition, the numbers of osteoblasts and osteoclasts were regulated in SM + K-administered rats but not different
from those in either SM or K-administered rats. In OVX rats, free Triiodothyronine (T3) and Thyroxine (T4) were similar
to control, ruling out the involvement of abnormal thyroid hormone. Although serum calcium is similar among all
the groups, estrogen level was higher especially in SM+K-administered rats. These results strongly suggest that SM+K
are effective in preventing the development of bone loss induced by OVX in rats.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Anderson GL / 2006 / Prior hormone therapy and breast cancer risk in the Women's Health Initiative randomized trial of estrogen plus progestin / Maturitas 55 (2) : 103 ~ 115
Chae HJ / 2004 / Prevention of bone loss in ovariectomized rats: the effect of Salvia miltiorrhiza extracts / Immunopharmacol Immunotoxicol 26 : 135 ~ 144
Chae HJ / 2007 / Effect of high molecular weight water-soluble chitosan on the trabecular bone and thickness in ovariectomized rats / Immunopharmacol Immunotoxicol 29 : 439
Chlebowski RT / 2009 / Breast cancer after use of estrogen plus progestin in postmenopausal women / N Engl J Med 360 (6) : 573 ~ 587
Gao Y / 2008 / Improvement of intestinal absorption of insulin and water-soluble macromolecular compounds by chitosan oligomers in rats / Int J Pharm 359 : 70 ~ 78
Chae HJ / 2004 / Prevention of bone loss in ovariectomized rats: the effect of Salvia miltiorrhiza extracts / Immunopharmacol Immunotoxicol 26 : 135 ~ 144
Chae HJ / 2007 / Effect of high molecular weight water-soluble chitosan on the trabecular bone and thickness in ovariectomized rats / Immunopharmacol Immunotoxicol 29 : 439
Chlebowski RT / 2009 / Breast cancer after use of estrogen plus progestin in postmenopausal women / N Engl J Med 360 (6) : 573 ~ 587
Gao Y / 2008 / Improvement of intestinal absorption of insulin and water-soluble macromolecular compounds by chitosan oligomers in rats / Int J Pharm 359 : 70 ~ 78
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