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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 510 - 517 (8page)
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초록· 키워드
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Phthalates, such as di (2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP), which have been shown to be teratogenic and disruptive of the endocrine system are metabolized rapidly and excreted in the urine. In this study, a simultaneous analytical method for 10 phthalate metabolites, MnBP, MiBP, MBzP, MCHP, MEHP, MEHHP, MEOHP, MnOP,MiNP and MiDP in human urine was developed based on a switching system with an on-line pretreatment column using HPLC-MS/MS. This method was validated according to the guidelines for bioanalytical method validation of the National Institute of Toxicological Research. The limits of the detection range were between 0.2 and 0.9 ng/ml for the 10 phthalate metabolites. The calibration curves showed linearity in the range of 0.997~0.999, and the results of the intra- and interday validations were in range from 0.4 to 14.7% RSD and from 0.3 to 9.4% RSD, respectively. Recovery of the phthalate metabolites varied from 87.0 to 116.1%. This analytical method exhibited a high degree of accuracy and stable precision for all of the metabolites, and appears to be suitable for the biomonitoring of phthalates in human urine.
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참고문헌 (23)
참고문헌 신청
/ 1981 / US Environmental Protection Agency : An exposureand risk assessment for phthalate ester : Di(2-ethylhexyl)phthalate, di-n-butyl phthalate, dimethyl phthalete,diethyl phthalate,
/ 1983 / Midwest Research Institute : Single and repeated oraldose pharmacokinetics of 14 C-labelled diisononylphthalate with cover letter / Midwest Research Institute
/ 2001 / US Food and Drug Administration : BioanalyticalMethod Validation / Food and Drug Administration
/ 2002 / National Institute of Technological Research : BioanalyticalMethod Validation / National Institute ofTechnological Research
/ 2005 / Center for Disease Contral and Prevention : ThirdNational Report on Human Exposure to EnvironmentalChemicals / Department of Health and Human Services,Centers for Disease Con
/ 1983 / Midwest Research Institute : Single and repeated oraldose pharmacokinetics of 14 C-labelled diisononylphthalate with cover letter / Midwest Research Institute
/ 2001 / US Food and Drug Administration : BioanalyticalMethod Validation / Food and Drug Administration
/ 2002 / National Institute of Technological Research : BioanalyticalMethod Validation / National Institute ofTechnological Research
/ 2005 / Center for Disease Contral and Prevention : ThirdNational Report on Human Exposure to EnvironmentalChemicals / Department of Health and Human Services,Centers for Disease Con
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