지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 126 - 134 (9page)
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초록· 키워드
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Objectives : The purpose of this study was to determine a separation method for each arsenic metabolite in urine by using a high performance liquid chromatography (HPLC)- inductively coupled plasma-mass spectrometer (ICP-MS).
Methods : Separation of the arsenic metabolites was conducted in urine by using a polymeric anion-exchange (Hamilton PRP X-100, 4.6 mm×150 mm, 5 μm) column on Agilent Technologies 1260 Infinity LC system coupled to Agilent Technologies 7700 series ICP/MS equipment using argon as the plasma gas.
Results : All five important arsenic metabolites in urine were separated within 16 minutes in the order of arsenobetaine, arsenite, dimethylarsinate, monomethylarsonate and arsenate with detection limits ranging from 0.15 to 0.27 μg/L (40 μL injection). We used GEQUAS No. 52, the German external quality assessment scheme and standard reference material 2669, National Institute of Standard and Technology, to validate our analyses.
Conclusions : The method for separation of arsenic metabolites in urine was established by using HPLC-ICP-MS. This method contributes to the evaluation of arsenic exposure, health effect assessment and other bio-monitoring studies for arsenic exposure in South Korea.
Methods : Separation of the arsenic metabolites was conducted in urine by using a polymeric anion-exchange (Hamilton PRP X-100, 4.6 mm×150 mm, 5 μm) column on Agilent Technologies 1260 Infinity LC system coupled to Agilent Technologies 7700 series ICP/MS equipment using argon as the plasma gas.
Results : All five important arsenic metabolites in urine were separated within 16 minutes in the order of arsenobetaine, arsenite, dimethylarsinate, monomethylarsonate and arsenate with detection limits ranging from 0.15 to 0.27 μg/L (40 μL injection). We used GEQUAS No. 52, the German external quality assessment scheme and standard reference material 2669, National Institute of Standard and Technology, to validate our analyses.
Conclusions : The method for separation of arsenic metabolites in urine was established by using HPLC-ICP-MS. This method contributes to the evaluation of arsenic exposure, health effect assessment and other bio-monitoring studies for arsenic exposure in South Korea.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (26)
참고문헌 신청
Gibb H / 2011 / Utility of recent studies to assess the National Research Council 2001 estimates of cancer risk from ingested arsenic / Environ Health Perspect 119(3):284~290
Argos M / 2010 / Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study / Lancet 376(9737):252~258
International Agency for Research on Cancer / Arsenic and arsenic compounds
Ferreccio C / 2000 / Lung cancer and arsenic concentrations in drinking water in Chile / Epidemiology 11(6):673~679
Rossman TG / 2004 / Evidence that arsenite acts as a cocarcinogen in skin cancer / Toxicol Appl Pharmacol 198(3):394~404
Argos M / 2010 / Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study / Lancet 376(9737):252~258
International Agency for Research on Cancer / Arsenic and arsenic compounds
Ferreccio C / 2000 / Lung cancer and arsenic concentrations in drinking water in Chile / Epidemiology 11(6):673~679
Rossman TG / 2004 / Evidence that arsenite acts as a cocarcinogen in skin cancer / Toxicol Appl Pharmacol 198(3):394~404
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UCI(KEPA) : I410-ECN-0101-2016-539-002083224