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Prioritization of Chemicals for Chronic/Carcinogenic Inhalation Testing
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만성발암성 흡입독성시험 우선순위 물질 선정 연구

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Type
Academic journal
Author
Journal
Korean Society of Envlromental Health 한국환경보건학회지 한국환경보건학회지 제43권 제1호 KCI Excellent Accredited Journal
Published
2017.1
Pages
23 - 41 (19page)

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Prioritization of Chemicals for Chronic/Carcinogenic Inhalation Testing
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Abstract· Keywords

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Objectives: In this study, we seek to perform a priority selection for test substances for chronic inhalation toxicity studies, including acute and subchronic inhalation toxicity studies, which are to be performed after the construction of a chronic/carcinogenicity inhalation toxicity study facility and enactment of pertinent legislation.Methods: Through this study, qualitative and quantitative priority evaluation of test substances according to acute, subchronic and chronic categories were respectively performed and priorities were suggested by expert group review, redundancy and other methods. Meanwhile, a draft on test substance selection criteria, procedures and methods referring to the National Toxicology Program (NTP) system was proposed.Results: This study selected priorities for candidate substances for chronic inhalation toxicity studies to be conducted from 2016.Conclusions: In the future, by assessing in advance the toxicological effects of chemicals to which workers can be potentially exposed in the workplace via long-term inhalation, expected health disturbances among workers will be reduced and it is anticipated that occupational disease induced by chemicals will be effectively prevented.
#Carcinogenicity #Chronic #Inhalation #Toxicity #Selection #Test substance

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References (19)

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Environment Canada / 1994 / The ARET substance selection process and guidelines google schola European Union / 2001 / General classification and labelling requirements for dangerous substances and preparations / Official J European Communities L : 225 ~ 263 google schola Hansen BG / 1999 / Priority setting for existing chemicals: European Union Risk Ranking Method / Environmental Toxicology and Chemistry 18 : 772 ~ 779 google schola Korea Occupational Safety and Health Agency / 2014 / Domestic business survey google schola Ministry of employment and labor / 2014 / Guideline for chemical hazard evaluation and risk assessment / 2014 An established rule No. 66 google schola

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