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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 709 - 714 (6page)
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초록· 키워드
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Background: The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. Objective: In the present in vitro study, we compared the effect of culture media supplemented with (a) thermal spa waters (La Roche-Posay, Avène) and (b) two natural mineral drinking waters (Heppinger, Adelholzener) on physiological parameters in HaCaT keratinocytes. Methods: The different medium preparations were investigated with regard to cell proliferation and cell damage. Moreover, the impact on inflammation parameters with and without ultraviolet B (UVB) irradiation was examined. Results: Two popular thermal spring waters were found to suppress cell proliferation and cell damage. Moreover, these waters reversed the induction of interleukin-6, as measured using enzyme-linked immunosorbent assay and promoter transactivation, and the formation of reactive oxygen species after UVB stimulation. Of note, the two natural mineral waters, which are distributed as drinking waters, had some effect on the above-mentioned parameters but to a lesser extent. Conclusion: In summary, our results show that spa waters, and particularly those derived from thermal springs, reduce parameters associated with inflammation. It seems likely that trace elements such as selenium and zinc are critical for the observed effects.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Cezanne L / 1993 / Effects of the Avene spring water on the dynamics of lipids in the membranes of cultured fibroblasts / Skin Pharmacol 6 : 231 ~ 240
Chebassier N / 2004 / Stimulatory effect of boron and manganese salts on keratinocyte migration / Acta Derm Venereol 84 : 191 ~ 194
Dorn A / 2007 / Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo / J Invest Dermatol 127 : 846 ~ 854
Dujic J / 2007 / Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light / J Invest Dermatol 127
Ho-Pyo Lee / 2012 / Effect of Spa Spring Water on Cytokine Expression in Human Keratinocyte HaCaT Cells and on Differentiation of CD4? T Cells / Annals of Dermatology 24 (3)
Chebassier N / 2004 / Stimulatory effect of boron and manganese salts on keratinocyte migration / Acta Derm Venereol 84 : 191 ~ 194
Dorn A / 2007 / Oligonucleotides suppress IL-8 in skin keratinocytes in vitro and offer anti-inflammatory properties in vivo / J Invest Dermatol 127 : 846 ~ 854
Dujic J / 2007 / Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light / J Invest Dermatol 127
Ho-Pyo Lee / 2012 / Effect of Spa Spring Water on Cytokine Expression in Human Keratinocyte HaCaT Cells and on Differentiation of CD4? T Cells / Annals of Dermatology 24 (3)
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