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Background: Generalized granuloma annulare (GGA) is abenign skin disorder of an unknown etiology. Though somecases of GGA have been reported, few systemic reviews ofthe clinical and pathological features of GGA have beenperformed. Objective: The purpose of this study is to analyzeand correlate the clinical and pathological characteristics ofGGA in Korean patients. Methods: We conducted a retrospectivestudy that included 54 biopsy specimens of KoreanGGA patients, and the clinical and pathological features ofGGA were reviewed and analyzed for their correlation. Results: The cutaneous lesions could be divided into theannular (24, 44%) and nonannular types (30, 56%), and thelesions were more common in males than in females (29males and 25 females). The incidence of GGA showed abimodal age distribution. The number of patients who presentedwithin the first decade was 24 cases (44%), and 24cases (44%) were over the fifth decade. Eight patients (15%)had systemic diseases. Especially, diabetes mellitus (DM)occurred only in the adult GGA patients over forty years old. The pathological findings showed dermal granulomatouslesions that consisted of either a palisading pattern (28, 52%)or an interstitial pattern (26, 48%). Conclusion: In contrast tothe previously reported studies, the age of GGA onsetshowed a bimodal distribution, and GGA was observedmore often in males. The prevalence of DM in the GGAaffected individuals was higher than that found in the generalKorean population. Therefore, it is recommended to performa work-up for DM in the GGA affected patients who are overforty years old.

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