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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 129 - 135 (7page)
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초록· 키워드
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Tumor suppressor gene O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been reported in melanoma. However, the clinical and prognostic significance of MGMT promoter methylation in patients with melanoma remained to be determined. A systematic search was performed to identify eligible papers published. The overall odds ratios (ORs) or hazard ratios and their 95% confidence intervals were calculated. Final 12 eligible publications involving Caucasian population were performed in this study, including 1,071 metastatic melanoma patients, 154 primary melanoma patients, and 211 normal controls. MGMT promoter methylation was significantly higher in primary or metastatic melanoma than in normal controls (p ＜0.05). No difference of MGMT promoter methylation was found in primary and metastatic melanoma (p=0.432). When metastatic melanoma was compared to normal controls, subgroup analysis showed the correlation between MGMT promoter methylation and different sample materials (tissue: OR=7.01, p＜0.001 and blood: OR=12.04, p=0.005). MGMT promoter methylation was not associated with response to drug therapy and the prognosis in overall survival and progression-free survival for multivariate analysis. Our results show that MGMT promoter methylation may be correlated with the increased risk of primary or metastatic melanoma. Based on blood samples, MGMT promoter methylation may become a noninvasive biomarker for the detection of metastatic melanoma. Further additional clinical studies are necessary.
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참고문헌 (25)
참고문헌 신청
Leucci E / 2016 / The emerging role of long non-coding RNAs in cutaneous melanoma / Pigment Cell Melanoma Res 29:619~626
Berwick M / 2016 / Melanoma epidemiology and prevention / Cancer Treat Res 167:17~49
Sarkar D / 2015 / Epigenetic regulation in human melanoma: past and future / Epigenetics 10:103~121
Ye M / 2017 / Diagnostic capacity of RASSF1A promoter methylation as a biomarker in tissue, brushing, and blood samples of nasopharyngeal carcinoma / EBioMedicine 18:32~40
Paska AV / 2015 / Aberrant methylation patterns in cancer: a clinical view / Biochem Med (Zagreb) 25:161~176
Berwick M / 2016 / Melanoma epidemiology and prevention / Cancer Treat Res 167:17~49
Sarkar D / 2015 / Epigenetic regulation in human melanoma: past and future / Epigenetics 10:103~121
Ye M / 2017 / Diagnostic capacity of RASSF1A promoter methylation as a biomarker in tissue, brushing, and blood samples of nasopharyngeal carcinoma / EBioMedicine 18:32~40
Paska AV / 2015 / Aberrant methylation patterns in cancer: a clinical view / Biochem Med (Zagreb) 25:161~176
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