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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 250 - 256 (7page)
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초록· 키워드
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Background: The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging. Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated a curative effect towards melasma and ultraviolet- induced PIH in Asian countries. However, the precise mechanism of its inhibitory effect on melanogenesis is not fully understood. Objective: In order to clarify the inhibitory effect of tranexamic acid on PIH, we investigated its effects on mouse melanocytes (i.e., melan-a cells) and human melanocytes. Methods: Melan-a cells and human melanocytes were cultured with fractional CO2 laser-treated keratinocyte- conditioned media. Melanin content and tyrosinase activity were evaluated in cells treated with or without tranexamic acid. Protein levels of tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 were evaluated in melan-a cells.
Signaling pathway molecules involved in melanogenesis in melanoma cells were also investigated. Results: Tranexamic acid-treated melanocytes exhibited reduced melanin content and tyrosinase activity. Tranexamic acid also decreased tyrosinase, TRP-1, and TRP-2 protein levels. This inhibitory effect on melanogenesis was considered to be involved in extracellular signal-regulated kinase signaling pathways and subsequently microphthalmia-associated transcription factor degradation. Conclusion: Tranexamic acid may be an attractive candidate for the treatment of PIH.
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참고문헌 (18)
참고문헌 신청
Ando H / 2007 / Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase / J Invest Dermatol 127 : 751 ~ 761
Burd A / 2005 / A study of Q-switched Nd:YAG laser irradiation and paracrine function in human skin cells / Photodermatol Photoimmunol Photomed 21 : 131 ~ 137
Chang TS / 2009 / An updated review of tyrosinase inhibitors / Int J Mol Sci 10 : 2440 ~ 2475
Costin GE / 2007 / Human skin pigmentation:melanocytes modulate skin color in response to stress / FASEB J 21 : 976 ~ 994
Dunn CJ / 1999 / Tranexamic acid: a review of its use in surgery and other indications / Drugs 57 : 1005 ~ 1032
Burd A / 2005 / A study of Q-switched Nd:YAG laser irradiation and paracrine function in human skin cells / Photodermatol Photoimmunol Photomed 21 : 131 ~ 137
Chang TS / 2009 / An updated review of tyrosinase inhibitors / Int J Mol Sci 10 : 2440 ~ 2475
Costin GE / 2007 / Human skin pigmentation:melanocytes modulate skin color in response to stress / FASEB J 21 : 976 ~ 994
Dunn CJ / 1999 / Tranexamic acid: a review of its use in surgery and other indications / Drugs 57 : 1005 ~ 1032
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