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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 156 - 162 (7page)
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초록· 키워드
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Background: Although molluscum contagiosum (MC) resolves spontaneously, there are several reasons to treat this dermatological disorder. Objective: To evaluate the safety and efficacy of 5% imiquimod cream versus 10% potassium hydroxide (KOH) solution in treating MC, and to propose the mechanism of cure by observing the histological findings.
Methods: Imiquimod or KOH were applied by the patient or a parent 3 days per week until all lesions cleared. The number of MC lesions was counted and side effects were evaluated at 5 points during the treatment (the initial visit,week 2, week 4, week 8, and week 12). Histological changes were compared between 2 patients of each group, before and after the 2 weeks of application. Results: In both group,the mean lesion counts decreased all through to week 12,and the reduction in number of lesions were statistically significant in both groups (p＜0.005). Over 40% of each group developed local side effects, and no systemic side effects were noted in either group. Before treatment,histological findings showed little or no dermal infiltrates.
After treatment, specimens showed dense lymphocytic infiltrates, especially T cells, around the lesions which had resolved. Conclusion: Both 10% KOH solution and 5%imiquimod cream are effective and safe treatment of MC.
(Ann Dermatol 22(2) 156∼162, 2010)
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Arany I / 1996 / Activation of local cell-mediated immunity in interferon-responsive patients with human papillomavirus-associated lesions / J Interferon Cytokine Res 16 : 4
Barba AR / 2001 / An open label safety study of topical imiquimod 5% cream in the treatment of Molluscum contagiosum in children / Dermatol Online J 7 : 20 ~
Bayerl C / 2003 / Experience in treating molluscum contagiosum in children with imiquimod 5% cream / Br J Dermatol 149 (Suppl 66) : 25 ~ 29
Callen JP / 2008 / Immunomodulators. In: Dermatology. 2nd ed / Mosby Elsevier : 1974 ~ 1989
Cathcart S / 2009 / Parental satisfaction,efficacy,and adverse events in 54 patients treated with cantharidin for molluscum contagiosum infection / Clin Pediatr(Phila) 48 : 1
Barba AR / 2001 / An open label safety study of topical imiquimod 5% cream in the treatment of Molluscum contagiosum in children / Dermatol Online J 7 : 20 ~
Bayerl C / 2003 / Experience in treating molluscum contagiosum in children with imiquimod 5% cream / Br J Dermatol 149 (Suppl 66) : 25 ~ 29
Callen JP / 2008 / Immunomodulators. In: Dermatology. 2nd ed / Mosby Elsevier : 1974 ~ 1989
Cathcart S / 2009 / Parental satisfaction,efficacy,and adverse events in 54 patients treated with cantharidin for molluscum contagiosum infection / Clin Pediatr(Phila) 48 : 1
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