지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 544 - 549 (6page)
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초록· 키워드
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Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by tissue- bound and circulating autoantibodies directed against BP180 and/or BP230 antigens. Various inflammatory cells are involved in the development of blister in BP. Objective: The aim of this study was to evaluate the correlation between peripheral leukocyte counts and BP severity. Methods: We retrospectively included 60 patients with BP, who had not been treated with systemic steroid at the time of blood sampling. The patients were classified into two groups, those with admission history (admission group) and those without admission history (non-admission group). Disease severity was evaluated using three parameters: admission history, initial steroid dosage, and modified version of a pemphigus scoring system. We evaluated the correlation between peripheral leukocyte counts and disease severity measured by the three parameters. Results: The admission group showed a significant increase in disease severity measured by initial steroid dosage and severity score compared with the non-admission group. Additionally, the admission group had increased total leukocyte, eosinophil, and neutrophil counts. In the correlation study, the peripheral eosinophil and neutrophil counts showed positive correlation with BP severity evaluated by both initial steroid dosage and the pemphigus scoring system. Conclusion: Peripheral eosinophil and neutrophil counts can be used as a marker in predicting disease severity in patients with BP.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Schmidt E / 2013 / Pemphigoid diseases / Lancet 381:320~332
Feliciani C / 2015 / Management of bullous pemphigoid: the European dermatology forum consensus in collaboration with the European Academy of Dermatology and Venereology / Br J Dermatol 172:867~877
Bagci IS / 2017 / Bullous pemphigoid / Autoimmun Rev 16:445~455
Bieber K / 2017 / Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid / Exp Dermatol 26:1248~1252
Rifaioglu EN / 2014 / Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid / Platelets 25:264~267
Feliciani C / 2015 / Management of bullous pemphigoid: the European dermatology forum consensus in collaboration with the European Academy of Dermatology and Venereology / Br J Dermatol 172:867~877
Bagci IS / 2017 / Bullous pemphigoid / Autoimmun Rev 16:445~455
Bieber K / 2017 / Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid / Exp Dermatol 26:1248~1252
Rifaioglu EN / 2014 / Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid / Platelets 25:264~267
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