지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 56 - 66 (11page)
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초록· 키워드
오류제보하기
Background: A disruption of the balance between the water content of the stratum corneum
(SC) and skin surface lipids may lead to the clinical manifestation of dryness of skin in patients
with atopic dermatitis (AD).
Objective: To determine whether supplementation of gromwell (Lithospermum erythrorhizon), one
of herbs used in East Asia in remedies for various abnormal skin conditions, may improve the
SC level of hydration and ceramides, major lipid in SC in patients with AD.
Methods: A total of 28 subjects with AD were randomly assigned into two groups: either
gromwell group received dextrose contained capsules with 1.5 g of gromwell extracts or placebo
group received only dextrose contained capsules for 10 weeks.
Results: In contrast to no alteration of SC hydration and ceramides in placebo group, the
SC hydration in gromwell group was significantly increased in parallel with an increase of SC
ceramides. Furthermore, % increase of SC hydration in gromwell group bore a positive correlation
with the clinical severity, which suggests that the increase of SC hydration in gromwell group
was more effective as AD was more severe.
Conclusion: Supplementation of gromwell improves SC hydration in parallel with an increase
of ceramides in part.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aioi A / 2001 / Impairment of skin barrier function in NC/Nga Tnd mice as a possible model for atopic dermatitis / Br J Dermatol 144 : 12 ~ 18
Arkwright PD / 2005 / Mycobacterium vaccae reduces scratching behavior but not the rash in NC mice with eczema: a randomized, blinded, placebo-controlled trial / J Invest De
Durnin JV / 2003 / The assessment of the amount of fat in the human body from measurements of skinfold thickness / Br J Nutr 89 : 147 ~ 155
Elias PM / 1991 / Structural and lipid biochemical correlates of the epidermal permeability barrier / Adv Lipid Res 24 : 1 ~ 26
Elias PM / 2005 / Stratum corneum defensive functions: an integrated view / J Invest Dermatol 125 : 183 ~ 200
Arkwright PD / 2005 / Mycobacterium vaccae reduces scratching behavior but not the rash in NC mice with eczema: a randomized, blinded, placebo-controlled trial / J Invest De
Durnin JV / 2003 / The assessment of the amount of fat in the human body from measurements of skinfold thickness / Br J Nutr 89 : 147 ~ 155
Elias PM / 1991 / Structural and lipid biochemical correlates of the epidermal permeability barrier / Adv Lipid Res 24 : 1 ~ 26
Elias PM / 2005 / Stratum corneum defensive functions: an integrated view / J Invest Dermatol 125 : 183 ~ 200
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