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자료유형
학술저널
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저널정보
대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제17권 제1호
발행연도
2004.1
수록면
5 - 5 (1page)

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Background: Adenosine has been shown to exert an antinociceptive effect under experimental conditions in animals and humans. This study was performed to evaluate the effects of adenosine on postoperative pain and intraoperative blood pressure changes. Methods: We studied 30 patients, aged <65 years, who underwent laparoscopic cholecystectomy under N2O-O2-isoflurane general anesthesia. Patients were randomized into two groups: an adenosine group (adenosine was infused continuously at 100-150 μg/kg/min, n = 15) and a control group (normal saline infused at 4 ml/min, n = 15). Mean arterial blood pressure during the intraoperative period, and pain score at 30 minutes, 6 hours, 24 hours, and 48 hours after operation were checked. On patient request, meperidine was administrated intravenously. Results: Pain scores and the cumulative doses of meperidine were much lower in the adenosine group than in the control group. The elevation of mean arterial pressure during pnemoperiton-eum was significantly attenuated in the adenosine group. Conclusions: This data suggests that intravenous adenosine infusion is effective at post-operative pain control following a laparoscopic cholecystectomy and that it is also effective at attenuating blood pressure elevation during pneumoperitoneum.

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