지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Bolus intravenous injection of adenosine resulted the temporal decrease of systemic blood pressure and heart rate in the anesthetized rats. Adenosine also resulted the persistent decrease of contractility and heart rate in the isolated spontaneously beating rat right atria. Both of the above inhibition effets of adenosine were increased by the pretreatment of NBI (nitrobenzylthioinosine), whitch is an adenosine transport inhibitor, but decreased by the pretreatment of 8-phenyltheophy1line, which is an adenosine antagonist. In isolated thoracic aorta ring segment of normotensive rats, intact rings were relaxed by adenosine (42.3±8.7%) and ATP (85.9±15.8%) in the concentration of 10^(-4) M, but rubbed rings were relaxed by adenosine (35.2±1.9%) and ATP (11.3±9.0%) in 10^(-4) M. After pretreatment of L-NAME (N-Nitro-Larginine methyl ester), which is an NO inhibitor, adenosine-induced relaxation was not affected, but ATP-induced relaxation was significantly inhibited (P<0.01). Meanwhile, adenosine resulted almost same as vasorelaxation in isolated thoracic aorta of SHR comparing to those of normotensive rats. But, vasodilation responses of ATP in intact rings of SHR are significantly inhibited comparing to those of normotensive rats. Adenosine-induced relaxation is attenuated after 8-phenyltheophylline pretreatment, but increased after NBI pretreatment. However, ATP-induced relaxations are not affected by 8-phenyltheophylline or NBI pretreatment. These results suggested that the hypotensive effects of adenosine was due to the decrease of contractile force and heart rate through the A1 receptor and vasodilation are mediated by A2 receptor of the vascular smooth muscle. And, the heart protective and vasodilation effects of adenosine might suggest that it would be useful in the acute treatment of coronary artery disease.
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참고문헌 (19)
참고문헌 신청
Belardinelli L / 1989 / The cardiac effects of adenosine / Prog Cardiovasc Dis 32 : 73 ~ 79
Burnstock, G / 1978 / A basis of distinguishing two types of purinergic receptors, in Cell Membrene Receptors for Drugs and Hormones / Raven : 107 ~ 111
Fruchgott RF / 1988 / Mechanism of vasodilators / Raven Press : 401 ~ 414
Gordon JL / 1983 / Endothelium-dependant relaxation of the pig aorta : relationship to stimulation of Rb efflux from isolated endothelial cells / Br pharmacol 79 : 531 ~ 541
Harrington LS / 2007 / Purinergic 2X1 receptors mediate endothelial dependent vasodilation to ATP / Mol Pharmacol 72 (5) : 1132 ~ 1136
Burnstock, G / 1978 / A basis of distinguishing two types of purinergic receptors, in Cell Membrene Receptors for Drugs and Hormones / Raven : 107 ~ 111
Fruchgott RF / 1988 / Mechanism of vasodilators / Raven Press : 401 ~ 414
Gordon JL / 1983 / Endothelium-dependant relaxation of the pig aorta : relationship to stimulation of Rb efflux from isolated endothelial cells / Br pharmacol 79 : 531 ~ 541
Harrington LS / 2007 / Purinergic 2X1 receptors mediate endothelial dependent vasodilation to ATP / Mol Pharmacol 72 (5) : 1132 ~ 1136
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