아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구

김지현; 이혜인; 박주희; 임윤영; 김범준; 임인석; 김명남; 김현석; 김종근; 한성훈; 조수묵; 김재현; 박기문

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자료유형: 학술저널

저자정보: 김지현 이혜인 박주희 임윤영 김범준 임인석 김명남 김현석 김종근 한성훈 조수묵 김재현 박기문

저널정보: 대한천식알레르기학회(구 대한알레르기학회) 천식 및 알레르기 천식 및 알레르기 제30권 제1호

발행연도: 2010.1

수록면: 36 - 42 (7page)

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Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD). Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD. Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment. Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P＜0.001 and P＜0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively). Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD.

#Taraxacum platycarpum #Atopic dermatitis

참고문헌 (27)

참고문헌 신청

Chang JK / 1997 / Seasonly wild flowers of Korea / Doseochulpan Nexus

Cheong H / 1998 / Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum / Planta Med 64 : 577 ~ 8

Czech W / 1992 / Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis / Br J Dermatol 126 : 351 ~ 5

Fiset PO / 2006 / Immunopathology of atopic dermatitis / J Allergy Clin Immunol 118 : 287 ~ 90

Gunnar S / 1970 / Immunoglobulin E in healed atopic dermatitis and after treatment with corticosteroids and azathioprine / Br J Dermatol 82 : 10 ~ 3

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Kim Jihyun

소속기관 Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences

주요연구분야 의약학 > 임상의학 > 내과학

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