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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 194 - 199 (6page)
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Background: Unmethylated CpG can induce Th1 and regulatory T cell immune responses and may modulate ovalbumin-induced mouse allergic asthma. However, the effects of CpG in a cockroach allergen asthma model have not yet been elucidated.
Objective: To evaluate whether unmethylated CpG can prevent the development of indoor allergen-induced allergic asthma.
Methods: Effects of CpG were evaluated using a cockroach allergen-induced mouse model. CpG and Blattella germanica (CR) allergen were co-administered intranasally, and methacholine airway hyperresponsiveness (MCh-AHR), inflammatory cells and cytokine profiles in BAL fluid and lung histology were evaluated.
Result: Co-administration of CpG with CR allergen can prevent the development of MCh-AHR and allergic inflammation in a CR-induced asthma mouse model. Eosinophils, lymphocytes, macrophages and neutrophils in BAL fluid were decreased by the co-administration of unmethylated CpG in an OVA-induced asthma model. The expression of IL-5, IL-13 and IFN-γ in BAL fluid was attenuated by the CpG. Peribronchial, perivascular inflammation, and goblet cell hyperplasia in respiratory epithelium were also markedly attenuated by the CpG.
Conclusion: These findings suggest that unmethylated CpG may have role in the immune modulation of allergic asthma induced by indoor allergens.
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참고문헌 (24)
참고문헌 신청
Ball TM / 2000 / Siblings, day-care attendance, and the risk of asthma and wheezing during childhood / New Engl J Med 343 : 538 ~ 543
Braun-Fahrlander C / 2002 / Environmental exposure to endotoxin and its relation to asthma in school-age children / New Engl J Med 347 : 869 ~ 877
Chapman MD / 2007 / Protease as Th2 adjuvants / Current Allergy Asthma Reports 7 : 363 ~ 367
Cho JY / 2004 / Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling / Am J Respir Cell Mol biol 30 : 651 ~ 661
Creticos PS / 2006 / Immunotheerpay with a ragweed-Tll-like receptor 9 aagonist vaccine for allergic rhinit / N Engl J Med 355 : 1445 ~ 1455
Braun-Fahrlander C / 2002 / Environmental exposure to endotoxin and its relation to asthma in school-age children / New Engl J Med 347 : 869 ~ 877
Chapman MD / 2007 / Protease as Th2 adjuvants / Current Allergy Asthma Reports 7 : 363 ~ 367
Cho JY / 2004 / Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling / Am J Respir Cell Mol biol 30 : 651 ~ 661
Creticos PS / 2006 / Immunotheerpay with a ragweed-Tll-like receptor 9 aagonist vaccine for allergic rhinit / N Engl J Med 355 : 1445 ~ 1455
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