무모생쥐를 이용한 Disk 형태(DTS) 미세침롤러의 피부안정성에 관한 연구

박귀영; 이진웅; 김동하; 임윤영; 김범준; 김명남

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자료유형: 학술저널

저자정보: 박귀영 이진웅 김동하 임윤영 김범준 김명남

저널정보: 대한천식알레르기학회(구 대한알레르기학회) 천식 및 알레르기 천식 및 알레르기 제30권 제3호

발행연도: 2010.1

수록면: 222 - 227 (6page)

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연구결과

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Background: The transdermal drug delivery system has been studied for several decades as an alternative tool. Even though it has many advantages such as stability of drug to the destination, safety to the liver, there are some limitations in crossing the stratum corneum. Microneedle can perforate the skin directly, which make it possible for drugs to penetrate into the subcutaneous tissue. Objective: The purpose of this study to evaluate the stability of Diskmicroneedle Therapy System (DTS) and directly compare them with conventional Microneedle Therapy System (MTSⓇ, Clinical Resolution Lab, California,USA). Method: We used 3 sizes of manual and electric Diskmicroneedle Therapy System (DTS; 0.25 mm, 1.0 mm and 1.5 mm) to perforate the skin. We performed a comparative study of 0.5 mm manual DTS and Microneedle Therapy System (MTSⓇ). To evaluate the stability, visual inspection and biopsy were conducted. Result: Manual and electric DTS of all 3 sizes did not induce significant abnormalities of the skin on visual inspection and biopsy. DTS and MTS produced similar results on the stability for the skin. Conclusion: Similar to the preexisting MTS, DTS is a safe transdermal delivery system, and the size should be chosen carefully.

#Diskmicroneedle therapy #Stability

참고문헌 (14)

참고문헌 신청

Al-Qallaf B / 2009 / Optimizing microneedle arrays to increase skin permeability for transdermal drug delivery / Ann N Y Acad Sci 1161 : 83 ~ 94

Badran MM / 2009 / Skin penetration enhancement by a microneedle device (Dermarollerⓡ) in vitro: dependency on needle size and applied formulation / J Eur Pharm Sci 36 : 51

Chabri F / 2004 / Microfabricated silicon microneedles for nonviral cutaneous gene delivery / Br J Dermatol 150 : 869 ~ 77

Gardenierss HJGE / 2003 / Silicon micromachined hollow microneedles for transdermal liquid transport / J Microelectromech Sys 12 : 855 ~ 62

Henry S / 1998 / McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery / J Pharm Sci 87 : 922 ~ 25

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박귀영

소속기관 Department of Dermatology Chung-Ang University College of Medicine Seoul Korea.

주요연구분야 의약학 > 임상의학 > 내과학

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이진웅