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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 269 - 276 (8page)
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초록· 키워드
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Background: Atopic dermatitis (AD) is a chronic cutaneous inflammatory disorder. Dehydroepiandrosterone (DHEA) is a sex hormone normally secreted from the adrenal gland and is used to treat various disorders. It decreases in the serum of AD patients and is known to attenuate dust mite- induced airway allergic responses associated with reduced Th2 cytokine.
Objective: The authors attempted investigate the effect of DHEA on AD-like skin lesions by reviewing the cytokine profile and specific IgE production in BALB/c mice sensitized with ovalbumin (OVA).
Method: Mice were sensitized by intraperitoneal injection of OVA, followed by epicutaneous sensitization for 5 weeks. DHEA was given by the oral route. After all mice were sacrificed at the end of the experiment, skin, spleen tissue and blood were harvested.
Result: Gross and histological examinations of skin lesions showed inflammation. The severity was mild or absent in DHEA-ingested mice and the number of inflammatory cells was significantly reduced. The IL-5 levels in the cultured splenocytes significantly decreased in the sensitized mice than in the control group. The IFN-γ/IL-5 ratio significantly increased in the sensitized mice.
Conclusion: DHEA ingestion may suppress OVA-induced AD-like skin lesions and prevents the cytokine production of Th2 cells.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Araghi-Niknam M / 1997 / Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus / Pro Soc Exp Biol
Azzi L / 2005 / Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone / J Invest Dermatol 124 : 22 ~ 27
Cui Y / 2008 / Effects of combined BCG and DHEA treatment in preventing the development of asthma / Immunol Invest 37 : 191 ~ 202
Daynes RA / 1989 / Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4 / Eur J Immunol 19 : 2319
Daynes RA / 1990 / Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells / Eur J I
Azzi L / 2005 / Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone / J Invest Dermatol 124 : 22 ~ 27
Cui Y / 2008 / Effects of combined BCG and DHEA treatment in preventing the development of asthma / Immunol Invest 37 : 191 ~ 202
Daynes RA / 1989 / Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4 / Eur J Immunol 19 : 2319
Daynes RA / 1990 / Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells / Eur J I
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