지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 256 - 261 (6page)
이용수
초록· 키워드
오류제보하기
Background: There have been some uncontrolled studies on clinical efficacy of high-dose intravenous immunoglobulin (IVIG) in patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).
Objective: This study was conducted to demonstrate the effectiveness of high-dose IVIG therapy in reducing mortality in Korean patients with SJS or TEN.
Method: Retrospective data from 2 patients with SJS, 4 patients with SJS/TEN and 3 patients with TEN treated with high-dose IVIG were analyzed.
Result: The total dose of IVIG administered was 1.0 gm/kg/day from 2 days to 1.0 gm/kg for 7 days. Of the 8 patients who showed good responses to IVIG, the mean time to objective responses was 2.0±1.4 days (range, 1 to 5 days). The length of stay in hospital was 22.8±9.2 days (range, 11 to 40 days). Two patients had poor outcomes. Based on the SCORTEN system, 3.2 patients (39.9%) were expected to die, but 2.0 patients (25.0%) died. However, there was no statistical significance (P＞0.05).
Conclusion: Therapy with high-dose IVIG showed a slightly improved mortality in patients with SJS, SJS/TEN overlap and TEN, but there was no statistical significance (P＞0.05). Although dramatic clinical improvement was noted in most patients, further nationwide multicenter clinical trials are required to evaluate the effectiveness of high-dose IVIG in the treatment of patients with SJS or TEN.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Araki Y / 2009 / Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset / Am J Ophthalmol 147 : 1004 ~ 1011
Bastuji-Garin S / 2000 / SCORTEN; A severity-of-illness score for toxic epidermal necrolysis / J Invest Dermatol 115 : 149 ~ 153
Campione E / 2003 / High-dose intravenous immunoglobulin for severe drug reactions: efficacy in toxic epidermal necrolysis / Acta Derm Venereol 83 : 430 ~ 432
Chaidemenos GC / 1997 / Plasmapheresis in toxic epidermal necrolysis / Int J Dermatol 36 : 218 ~ 212
Chung W / 2004 / Medical genetics: a marker for Stevens-Johnson syndrome / Nature 428 : 486 ~
Bastuji-Garin S / 2000 / SCORTEN; A severity-of-illness score for toxic epidermal necrolysis / J Invest Dermatol 115 : 149 ~ 153
Campione E / 2003 / High-dose intravenous immunoglobulin for severe drug reactions: efficacy in toxic epidermal necrolysis / Acta Derm Venereol 83 : 430 ~ 432
Chaidemenos GC / 1997 / Plasmapheresis in toxic epidermal necrolysis / Int J Dermatol 36 : 218 ~ 212
Chung W / 2004 / Medical genetics: a marker for Stevens-Johnson syndrome / Nature 428 : 486 ~
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