지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune-complex-mediatedhypersensitivity reactions that predominantly involve skin and mucous membranes. Despite the low incidence, both areconsidered medical emergencies as the mortality rate has been estimated at 30-50%. Although as many as half of casesare idiopathic, several drugs have been implicated as main cause of SJS/TEN. This review therefore aimed to identifydrugs that were potentially associated with SJS/TEN and compare the relative risk of the medications. Method: A comprehensivesearch was performed using MEDLINE, EMBASE and 5 Korean databases. We defined study drugs as nonsteroidalanti-inflammatory drugs (NSAIDs), antibiotics, antiepileptics, and allopurinol. Only epidemiologic studiesinvestigating associations between the above drugs and drug-induced SJS/TEN were included. Two reviewers independentlyselected and evaluated candidate papers and extracted odds ratios or incidence rates. Meta-analysis was performedonly for drugs that were reported from 4 or more studies. Results: We found 8 case-control studies, 3 cohortstudies and 1 RCT. The ranges of adjusted ORs were 0.6-34.0 for NSAIDs, 1.6-302.0 for antiepileptics, 0.3-10.0 forantibiotics and 1.0-187.0 for allopurinol. The drug with the highest incidence of SJS/TEN was carbamazepine (40 persons/1,000 DDD). Conclusion: Finally, the risk was highest in first 8 weeks after onset of treatment in all drugs.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ / Korean medical library engine
/ / Scottish Intercollegiate Guidelines Network
/ / http://clinicalevidence.bmj.com/x/set/static/ebm/learn/ 665076.html
Auquier DA / 2002 / Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis / Arch Dermatol 1
Barvaliya M / 2011 / Drug-induced Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap: a multicentric retrospective study / J Postgrad Med 5
/ / Scottish Intercollegiate Guidelines Network
/ / http://clinicalevidence.bmj.com/x/set/static/ebm/learn/ 665076.html
Auquier DA / 2002 / Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis / Arch Dermatol 1
Barvaliya M / 2011 / Drug-induced Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap: a multicentric retrospective study / J Postgrad Med 5
이 논문의 저자 정보
최근 본 자료
댓글(0)
0