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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 238 - 243 (6page)
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초록· 키워드
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Purpose: Experimental autoimmune uveoretinitis (EAU) is an animal model of posterior uveitis and heme oxygenase-1 (HO-1) is a well-known anti-oxidant factor. However, there is no report a protective role of HO-1 on EAU in vivo. To verify that HO-1 is induced in EAU by interphotoreceptor retinoid-binding protein (IRBP), that an HO-1 inducers ameliorates the associated inflammation, and that an HO-1 inhibitor exacerbates this inflammation.
Methods: Forty four Lewis rats were given either 40 mol/kg hemin or 40 mol/kg SnPP (tin protoporphyrin IX) by intraperitoneal injection and twenty two uveitis control rats were injected with 0.5 mL of saline once daily 5-20 days after IRBP immunization inducing EAU. Three normal control rats were used for Western blotting and ELISA assay of HO-1. The clinical uveitis signs of inflammation were scored in the three groups from 0 to 4 on alternate three days. To confirm the clinical results, histological and immunohistochemical stain of HO-1 were performed on the day of peak inflammation and Western blotting and ELISA assay of HO-1 were performed on 6th, 12th and 18th day after IRBP immunization.
Results: Hemin, an inducer of HO-1, ameliorated the clinical signs of EAU. In contrast, SnPP-treated rats show that the severity of the clinical sign were exacerbated at the peak period of the disease. These results are roughly compatible with histological, immunoblotting, and immunohistochemical evaluations and an ELISA assay of HO-1.
Conclusions: We suggest that HO-1 plays an important protective role in EAU.
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참고문헌 (23)
참고문헌 신청
/ / Kappas A. Dual control mechanism for heme oxygenase tin protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Pro
Abraham NG / / Schwartzman ML. Presence of heme oxygenase and NADPH cytochrome P-450 reductase in human corneal epithelium. Invest Ophthalmol Vis Sci 1987 : 1464 ~ 72
Abraham NG / 1996 / The biological significance and physiological role of heme oxygenase 6 : 129 ~ 168
Andreoli TE / 2000 / Free radicals and oxidative stress 108 : 650 ~ 651
Chung H / / Choi DG. Clinical Analysis of Uveitis : 33 ~ 7
Abraham NG / / Schwartzman ML. Presence of heme oxygenase and NADPH cytochrome P-450 reductase in human corneal epithelium. Invest Ophthalmol Vis Sci 1987 : 1464 ~ 72
Abraham NG / 1996 / The biological significance and physiological role of heme oxygenase 6 : 129 ~ 168
Andreoli TE / 2000 / Free radicals and oxidative stress 108 : 650 ~ 651
Chung H / / Choi DG. Clinical Analysis of Uveitis : 33 ~ 7
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