지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 123 - 129 (7page)
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초록· 키워드
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Purpose: To investigate the short-term efficacy of topical immunosuppressive agents on the survival of cultivated allo-conjunctival equivalents.
Methods: Twenty-five eyes of New Zealand white rabbits were included. Temporal conjunctivae were trephined to a diameter of 7.5 mm, and then cultured allo-conjunctival epithelial cells on amniotic membrane were transplanted onto them. Various immunosuppressants including steroid, cyclosporine, and rapamycin were applied topically four times a day for a week. Epithelial defects and graft edema were graded daily. Numbers of inflammatory cells were measured in H&E. PKH26 and cytokeratin 4 and 7 were immunostained.
Results: Earlier epithelialization was observed in 1% steroid-treated eyes and defects persisted significantly in 0.5% CsA applied eyes. In histology, PKH26 positive cells considered as donor cells were only found in 1% steroid or 0.01% rapamycin applied eyes. 1% steroid- or 0.01% rapamycin-applied eyes both showed positive staining for keratin-4 and -7. Inflammatory cells were less found in 1% steroid or 0.01% rapamycin treated eyes.
Conclusions: Topical steroid or rapamycin can help to suppress acute inflammation and enhance the acute survival of transplanted conjunctival cells.
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참고문헌 (25)
참고문헌 신청
Ang LP / 2004 / Development of a conjunctival epithelial equivalent with improved proliferative properties using a multistep serum?free culture system / Invest Ophthalmol Vi
Ang LP / 2004 / The in vitro and in vivo proliferative capacity of serum?free cultivated human conjunctival epithelial c / Curr Eye Res 28 : 307 ~ 17
Ang LP / 2005 / Autologous cultivated conjunctival transplanta
Ang LP / 2006 / The development of a serum?free derived bioengineered conjunctival epithelial equivalent using an ultrathin poly (epsilon?caprolactone) membrane substrate /
Bell TA / 1986 / Cyclosporin A: tissue levels following topical and systemic administration to rabbits / Br J Ophthalmol 70 : 852 ~ 5
Ang LP / 2004 / The in vitro and in vivo proliferative capacity of serum?free cultivated human conjunctival epithelial c / Curr Eye Res 28 : 307 ~ 17
Ang LP / 2005 / Autologous cultivated conjunctival transplanta
Ang LP / 2006 / The development of a serum?free derived bioengineered conjunctival epithelial equivalent using an ultrathin poly (epsilon?caprolactone) membrane substrate /
Bell TA / 1986 / Cyclosporin A: tissue levels following topical and systemic administration to rabbits / Br J Ophthalmol 70 : 852 ~ 5
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