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Changes in Corneal Endothelial Cell after Ahmed Glaucoma Valve Implantation and Trabeculectomy: 1-Year Follow-up
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논문 기본 정보

Type
Academic journal
Author
Journal
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제30권 제6호 KCI Accredited Journals
Published
2016.1
Pages
416 - 425 (10page)

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Changes in Corneal Endothelial Cell after Ahmed Glaucoma Valve Implantation and Trabeculectomy: 1-Year Follow-up
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Purpose: To compare changes in corneal endothelial cell density (CECD) after Ahmed glaucoma valve (AGV)implantation and trabeculectomy. Methods: Changes in corneal endothelium in patients that underwent AGV implantation or trabeculectomy wereprospectively evaluated. Corneal specular microscopy was performed at the central cornea using a non-contactspecular microscope before surgery and 6 months and 12 months after surgery. The CECD, hexagonalityof the endothelial cells, and the coefficient of variation of the cell areas were compared between the twogroups. Results: Forty eyes of 40 patients with AGV implantation and 28 eyes of 28 patients with trabeculectomy werestudied. Intraocular pressure in the AGV implantation group was significantly higher than that in the trabeculectomygroup (p < 0.001), but there was no significant difference in other clinical variables between thetwo groups. In the AGV implantation group, the mean CECD significantly decreased by 9.4% at 6 months and12.3% at 12 months compared with baseline values (both, p < 0.001), while it decreased by 1.9% at 6 monthsand 3.2% at 12 months in the trabeculectomy group (p = 0.027 and p = 0.015, respectively). The changes at6 months and 12 months in the AGV implantation group were significantly higher than those in the trabeculectomygroup (p = 0.030 and p = 0.027, respectively). In the AGV implantation group, there was a significantdecrease in the CECD between baseline and 6 months and between 6 months and 12 months (p < 0.001 andp = 0.005, respectively). However, in the trabeculectomy group, a significant decrease was observed only betweenbaseline and 6 months (p = 0.027). Conclusions: Both the AGV implantation group and the trabeculectomy group showed statistically significantdecreases in the CECD 1 year after surgery. The decrease in CECD in the AVG implantation group was greaterand persisted longer than that in the trabeculectomy group.
#Key Words: Corneal endothelial cell loss #Glaucoma drainage implants #Trabeculectomy

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Laule A / 1978 / Endothelial cell population changes of human cornea during life / Arch Ophthalmol 96:2031~2035 google schola Freegard TJ / 1997 / The physical basis of transparency of the normal cornea / Eye (Lond) 11(Pt 4):465~471 google schola Bourne WM / 1997 / Central corneal endothelial cell changes over a ten-year period / Invest Ophthalmol Vis Sci 38:779~782 google schola Tuft SJ / 1990 / The corneal endothelium / Eye (Lond) 4(Pt 3):389~424 google schola Mishima S / 1982 / Clinical investigations on the corneal endothelium-XXXVIII Edward Jackson memorial lecture / Am J Ophthalmol 93:1~29 google schola

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