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자료유형
학술저널
저자정보
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제61권 제4호
발행연도
2018.1
수록면
497 - 504 (8page)

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ObjectiveTo compare the clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) in frozen embryo transfers (FETs)following either freeze-all policy to prevent ovarian hyperstimulation syndrome (OHSS; freeze-all group) or excessembryo cryopreservation after fresh embryo transfer (surplus group). MethodsThe freeze-all group comprised 44 FET cycles performed in 25 women between 2010 and 2016. The surplus groupcomprised 53 FET cycles performed in 47 women during the same period. The cumulative CPR and OPR according toduration of cryopreservation (interval between cryopreservation and FET) was estimated using Kaplan-Meier plots. Cox regression analysis was used for identifying factor to affect to cryopreservation duration in cycles with pregnancy. ResultsIn day 2–4 transfer cycles, the crude CPR (40% vs. 18.2%) and OPR (20% vs. 4.5%) were similar between the 2 groups. In day 5 transfer, the crude CPR (33.3% vs. 38.7%) and OPR (33.3% vs. 29%) were also similar between the 2 groups. The cumulative CPR (100% vs. 47.5%) and OPR (100% vs. 33.3%) in day 2–4 transfer as well as the cumulative CPR(46.7% vs. 100%) and OPR (46.7% and 74.8%) in day 5 transfer were also similar between the 2 groups. The medianduration of cryopreservation was significantly shorter in the freeze-all group than in the surplus group (19.8 vs. 36.9weeks, P=0.04). Previous history of delivery was the only factor associated with a shorter cryopreservation duration incycles with pregnancy (hazard ratio, 0.18; 95% confidence interval, 0.05–0.65; P=0.01). ConclusionFreezing embryos to prevent OHSS and transferring the frozen embryos later may guarantee an acceptablereproductive outcome.

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