지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 209 - 215 (7page)
이용수
초록· 키워드
오류제보하기
Preoperative neoadjuvant chemotherapy using cisplatin and 5-FU is generally given in oral and maxillofacial cancer. At tissue level both inflammation
and fibrosis occur after chemotherapy. The cellular changes mimic those of a granulating wound, with activated macrophages and fibroblasts
replacing the malignant cells as they are erradicated. Stromal cells, together with extracellular matrix components, provide the microenvironment that
is pivotal for tumor cell growth, invasion, and metastatic progression. Vascular endothelial growth factor(VEGF), an important regulator of angiogenesis
in cancer, induces mitogenesis of vascular endothelial cells, and vascular permeabilization and microvessel formation in a tumor are associated
with tumor nutrition and oxygenation. Also, they are associated with chemotherapeutic drug delivery. Oxygen delivery to tumor appears to rely on a
network of microvessels, On the other hand, the tumor microvessel is clearly an important factor in chemotherapeutic drug delivery to cancer cells,
and the efficacy of drug delivery can be high in richly vascularized tumors. So, this study was conducted to evaluate the effect of neoadjuvant
chemotherapy on microvessel density from 11 patients with tongue cancers. Our results showed that neoadjuvant chemotherapy was seemed to
decrease VEGF expression in tumor cells, however, it did not significantly alter VEGF expression in tumor-associated macrophages. Also,
Neoadjuvant chemotherapy had little effect on the microvessel density using CD34, and tumor-associated macrophage level using CD68. Thus, tumorassociated
macrophages seem to be the key factor associated with the maintenance of microvessel density after neoadjuvant chemotherapy in tongue
cancer.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
/ 1995 / Angiogenesis in bladder cancer:relationship between microves-sel density and tumor prognosis 87 : 1603 ~ 1612
/ 1995 / Oncogenes as inducers of tumor angiogenesis 14 : 263 ~ 277
/ 1996 / Association of macrophage infiltration with angiogenesis and progno-sis in invasive breast carcinoma 56 : 4625 ~ 4629
/ 1996 / Vesiculo-vacuo-lar organelles and the regulation of venule permeability to macromol-ecules by vascular permeability factor,histamine,and serotonin 83 : 1981 ~ 1986
/ 1997 / A comparative histopatho-logical study of the influence of chemo- and radiotherapy on humanprostatic carcinoma grown in nude mice 49 : 249 ~ 252
/ 1995 / Oncogenes as inducers of tumor angiogenesis 14 : 263 ~ 277
/ 1996 / Association of macrophage infiltration with angiogenesis and progno-sis in invasive breast carcinoma 56 : 4625 ~ 4629
/ 1996 / Vesiculo-vacuo-lar organelles and the regulation of venule permeability to macromol-ecules by vascular permeability factor,histamine,and serotonin 83 : 1981 ~ 1986
/ 1997 / A comparative histopatho-logical study of the influence of chemo- and radiotherapy on humanprostatic carcinoma grown in nude mice 49 : 249 ~ 252
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
갑상선 종양에서 VEGF(Vascular Endothelial Growth Factor)의 발현과 신생혈관생성
대한 두경부 종양 학술지
2004 .01
-
신세포암에서 미세혈관밀도 정량화를 위한 영상분석
Healthcare Informatics Research
2009 .01
-
Role of Neoadjuvant Chemotherapy in the Management of Advanced Ovarian Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
What Should We Do, If We Cannot Find The Tumor after Neoadjuvant Therapy?
대한외과학회 학술대회 초록집
2019 .10
-
Tumor-infiltrating Lymphocytes after Neoadjuvant Chemotherapy in Breast Cancer
대한외과학회 학술대회 초록집
2003 .11
-
유방암에 대한 술전항암화학요법(Neoadjuvant Chemotherapy)의 반응도에 따른 잔여종양조직의 병리학적 특성
Annals of Surgical Treatment and Research
2008 .07
-
유방암에서 수술 전 항암화학요법이 생물학적 예후인자들에 미치는 영향
Annals of Surgical Treatment and Research
2008 .06
-
Pathologic findings of residual tumor according to response rate after neoadjuvant chemotherapy in breast cancer
대한임상종양학회 학술대회지
2007 .09
-
두경부 편평세포암종에서 VEGF(vascular endothelial growth factor)의 발현 및 신생혈관생성
대한기관식도과학회지
2002 .01
-
Experience of AC Neoadjuvant Chemotherapy of Primary Small Cell Neuroendocrine Tumor of Breast
대한외과학회 학술대회 초록집
2006 .11
-
유방암에서 종양 미세혈관 밀도와예후와의 상관성
Annals of Surgical Treatment and Research
1998 .04
-
Human Lung Cancer에서 면역세포화학적 방법을 이용한 Tumor Angiogenesis에 관한 연구
Tuberculosis and Respiratory Diseases
1996 .01
-
Correlation of Mast Cell Densities, Angiogenesis and Vascular Endothelial Growth Factor in Proper Muscle GastricCarcinomas
Cancer Research and Treatment
2002 .01
-
Matrix Metalloproteinases(MMPs) 및 Vascular Endothelial Growth Factor(VEGF)의 발현을 통한 구강 설암의 침윤 기전 연구
대한 두경부 종양 학술지
2005 .01
-
The Role of Neoadjuvant Chemotherapy in Patients with ER Positive and HER2 Negative Breast Cancer
대한외과학회 학술대회 초록집
2018 .11
-
Differences in prognosis by p53 expression after neoadjuvant chemotherapy in triple-negative breast cancer
Annals of Surgical Treatment and Research
2020 .06
-
Neoadjuvant Chemotherapy in Colorectal Cancer : Liver Metastasis를 중심으로
대한임상종양학회 학술대회지
2008 .11
-
Current Issues in Neoadjuvant Cancer Treatment
대한임상종양학회 학술대회지
2014 .03
-
The Effect of Neoadjuvant Chemotherapy on Biological Prognostic Markers in Breast Cancer
대한외과학회 학술대회 초록집
2006 .11
-
위암에서의 선행화학요법
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2008 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0