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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 135 - 140 (6page)
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Loss of E-cadherin (E-cad) expression has been found in multiple cancers and is postulated to facilitate tumor cell dissociation and metastais. Promotor methylation may provides an alternative pathway for loss of gene function. This study evaluated the role of hypermethylation in the down-regulation of E-cad in oral squamous cell carcinoma (OSCC). We examined the E-cad expression by immunohistochemical staining and detected methylation status by methylation-specific polymerase chain reaction (MSP) in 20 OSCC tissues. Overally, 12 (60%) cases of hypermethylation of E-cad were detected and we found there were no correlation between methylation and age, histologic grade, lympn node metastasis, tumor size and clinical stage. However, Eleven (73.3%) of 15 samples which was negative for E-cad staining showed hypermethylation of E-cad promotor region. On the other hand, only one (20%) of 5 E-cad positive sample was observed with methylated status. The underexpression of E-cad was found to be related to promotor hypermethylation (p=0.035). In conclusion, we suggest that hypermethylation play a role in inactivation of E-cad gene and may be a appreciable biomarker for diagnosis and treatment of OSCC.
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참고문헌 (25)
참고문헌 신청
Bornman DM / 2001 / Methylation of the E-cadherin gene in bladder neoplasia and in normal uroepitheliaum from elderly individuals / Am J Pathol 34 : 187 ~ 198
Carter BS / 1990 / Allelic loss of chromosomes 16q and 10q in human prostate cancer / Proc Natl Acad Sci USA 87 : 8751 ~ 8755
Chang HW / 2002 / Loss of Ecadherin expression resulting from promotor hypermethylation in oral tongue carcinoma and tis prognostic significance / Cancer 94 : 386 ~ 392
Esteller M / 2001 / A gene hypermethylation profile of human cancer / Cancer Res 61 : 3225 ~ 3229
Graff JR / 2000 / Methylation patterns of the E-cadherin 5’CpG islands are unstable and reflect dynamic, heterogenous loss of E-cadherin expression during metastatic progre
Carter BS / 1990 / Allelic loss of chromosomes 16q and 10q in human prostate cancer / Proc Natl Acad Sci USA 87 : 8751 ~ 8755
Chang HW / 2002 / Loss of Ecadherin expression resulting from promotor hypermethylation in oral tongue carcinoma and tis prognostic significance / Cancer 94 : 386 ~ 392
Esteller M / 2001 / A gene hypermethylation profile of human cancer / Cancer Res 61 : 3225 ~ 3229
Graff JR / 2000 / Methylation patterns of the E-cadherin 5’CpG islands are unstable and reflect dynamic, heterogenous loss of E-cadherin expression during metastatic progre
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