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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제8호
- 발행연도
- 2018.1
- 수록면
- 1,339 - 1,345 (7page)
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초록· 키워드
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2-Keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, which catalyzes aldol cleavage and condensation reactions, has two distinct substrate-binding sites. The substrate-binding mode at the catalytic site and Schiff-base formation have been well studied. However, structural information on the phosphate-binding loop (P-loop) is limited. Zymomonas mobilis KDPG aldolase is one of the aldolases with a wide substrate spectrum. Its structure in complex with the substrate-mimicking 3-phosphoglycerate (3PG) shows that the phosphate moiety of 3PG interacts with the P-loop and a nearby conserved serine residue. 3PG-binding to the P-loop replaces water molecules aligned from the P-loop to the catalytic site, as observed in the apostructure. The extra electron density near the P-loop and comparison with other aldolases suggest the diversity and flexibility of the serine-containing loop among KDPG aldolases. These structural data may help to understand the substrate-binding mode and the broad substrate specificity of the Zymomonas KDPG aldolase.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Romano AH / 1996 / Evolution of carbohydrate metabolic pathways / Res. Microbiol. 147:448~455
Seo JS / 2005 / The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4 / Nat. Biotechnol. 23:63~68
Conway T / 1991 / Cloning, characterization, and expression of the Zymomonas mobilis edagene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway / Mol. Microbiol. 5:2901~2911
Allard J / 2001 / Covalent intermediate trapped in 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase structure at 1.95-A resolution / Proc. Natl. Acad. Sci. USA 98:3679~3684
Bell BJ / 2003 / Structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida / Acta Crystallogr. D Biol. Crystallogr. 59:1454~1458
Seo JS / 2005 / The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4 / Nat. Biotechnol. 23:63~68
Conway T / 1991 / Cloning, characterization, and expression of the Zymomonas mobilis edagene that encodes 2-keto-3-deoxy-6-phosphogluconate aldolase of the Entner-Doudoroff pathway / Mol. Microbiol. 5:2901~2911
Allard J / 2001 / Covalent intermediate trapped in 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase structure at 1.95-A resolution / Proc. Natl. Acad. Sci. USA 98:3679~3684
Bell BJ / 2003 / Structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Pseudomonas putida / Acta Crystallogr. D Biol. Crystallogr. 59:1454~1458
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