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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제1호
- 발행연도
- 2017.1
- 수록면
- 171 - 178 (8page)
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초록· 키워드
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A series of novel effector molecules secreted by the type three secretion system (T3SS) of Shigella spp. have been reported in recent years. In this study, a proteomic approach was applied to study T3SS effectors systematically. First, proteins secreted by the S. flexneri wildtype strain after Congo Red induction were separated and identified using two-dimensional electrophoresis to display the relative abundance of all kinds of early effectors for the first time. Then, a gene deletion mutant of known virulence repressor (OspD1) and a gene overexpressed mutant of two known virulence activators (MxiE and IpgC) were constructed and analyzed to discover potential late effectors. Furthermore, the supernatant proteins of gene deletion mutants of two known translocators (IpaB and IpaD), which would constantly secrete effectors, were also analyzed. Among all of the secreted proteins identified in our study, IpaH1.4, IpaH_5, and IpaH_7 have not been reported before. These proteomics data of the secreted effectors will be valuable to understand the pathogenesis of S. flexneri.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)]
Bahrani FK / 1997 / Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation / Infect. Immun 65 : 4005 ~ 4010
Barta ML / 2012 / Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure / Proteins 80 : 935 ~ 945
Bourdet-Sicard R / 1999 / Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization / EMBO J 18 : 5853 ~ 5862
Brotcke Zumsteg A / 2014 / IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis / Cell Host Microbe 15 : 435 ~ 445
Bahrani FK / 1997 / Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation / Infect. Immun 65 : 4005 ~ 4010
Barta ML / 2012 / Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure / Proteins 80 : 935 ~ 945
Bourdet-Sicard R / 1999 / Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization / EMBO J 18 : 5853 ~ 5862
Brotcke Zumsteg A / 2014 / IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis / Cell Host Microbe 15 : 435 ~ 445
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