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논문 기본 정보
- 자료유형
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- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제6호
- 발행연도
- 2016.1
- 수록면
- 999 - 1,010 (12page)
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초록· 키워드
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Ganoderma lucidum BCCM 31549 has a long established role for its therapeutic activities. In this context, much interest has focused on the possible functions of the (1,3)-β-D-glucan (G) produced by these cultures in a stirred-tank bioreactor and extracted from their underutilized mycelium. In the existing study, we report on the systematic production of G, and its sulfated derivative (GS). The aim of this study was to investigate G and its GS from G. lucidum in terms of their antibacterial properties and cytotoxicity spectrum against human prostate cells (PN2TA) and human caucasian histiocytic lymphoma cells (U937). 1H NMR for both G and GS compounds showed β-glycosidic linkages and structural similarities when compared with two standards (laminarin and fucoidan). The existence of characteristic absorptions at 1,170 and 867 cm-1 in the FTIR (Fourier Transform Infrared Spectroscopy) for GS demonstrated the successful sulfation of G. Only GS exhibited antimicrobial activity against a varied range of test bacteria of relevance to foodstuffs and human health. Moreover, both G and GS did not show any cytotoxic effects on PN2TA cells, thus helping demonstrate the safety of these polymers. Moreover, GS showed 40% antiproliferation against cancerous U937 cells at the low concentration (60 μg/ ml) applied in this study compared with G (10%). Together, this demonstrates that sulfation clearly improved the solubility and therapeutic activities of G. The water-soluble GS demonstrates the potential multifunctional effects of these materials in foodstuffs.
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참고문헌 (40)
참고문헌 신청
Alvarez-Suarez JM / 2010 / Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds / Food Chem. Toxicol 48:2490~2499
Bao H / 2010 / Effect of sulfated modification on the molecular characteristics and biological activities of polysaccharides from Hypsizigus marmoreus / Biosci. Biotechnol. Biochem 74:1408~1414
Bao XF / 2002 / Structural features of immunologically active polysaccharides from Ganoderma lucidum / Phytochemistry 59:175~181
Cechinel-Filho V / 2012 / Plant Bioactives and Drug Discovery:Principles, Practice, and Perspectives / John Wiley & Sons, Inc
Chen S / 2010 / Sulfation of a squid ink polysaccharide and its inhibitory effect on tumor cell metastasis / Carbohydr. Polym 81:560~566
Bao H / 2010 / Effect of sulfated modification on the molecular characteristics and biological activities of polysaccharides from Hypsizigus marmoreus / Biosci. Biotechnol. Biochem 74:1408~1414
Bao XF / 2002 / Structural features of immunologically active polysaccharides from Ganoderma lucidum / Phytochemistry 59:175~181
Cechinel-Filho V / 2012 / Plant Bioactives and Drug Discovery:Principles, Practice, and Perspectives / John Wiley & Sons, Inc
Chen S / 2010 / Sulfation of a squid ink polysaccharide and its inhibitory effect on tumor cell metastasis / Carbohydr. Polym 81:560~566
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