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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제2호
- 발행연도
- 2010.1
- 수록면
- 287 - 293 (7page)
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Reliable discrimination of a single nucleotide mismatch was demonstrated using arrays with peptide nucleic acid (PNA) probes. The newly developed PNA probes immobilization method and hybridization conditions for PNA arrays gave excellent specificity and sensitivity. In addition we compared the specificity, sensitivity, and stability obtained with the PNA and DNA arrays in discriminating single nucleotide mismatches. The PNA arrays had superior perfect match-to-mismatch signal ratios and sensitivities. The relative signal intensities of mismatch PNA probes ranged from 1.6% to 12.1% of the perfect-match PNA probes. These results demonstrated that the PNA arrays were 2.0 to 37.3 times more specific and about 10 times more sensitive than DNA arrays. The PNA array showed the same specificity and sensitivity after 12-month storage at room temperature.
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참고문헌 (26)
참고문헌 신청
Auburn, R. P / 2005 / Robotic spotting of cDNA and oligonucleotide microarrays / Trends Biotechnol 23 : 374 ~ 379
Beuvinky, I / 2007 / A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs / Nucleic Acids Res 35 : 1 ~ 11
Brandt, O / 2003 / PNA microarrays for hybridisation of unlabelled DNA samples / Nucleic Acids Res 31 : e119 ~
Brandt, O / 2004 / Peptide nucleic acids on microarrays and other biosensors / Trends Biotechnol 22 : 617 ~ 622
Chiu, S.-K / 2003 / Synergistic effects of epoxy- and amine-silanes on microarray DNA immobilization and hybridization / Biochem. J 374 : 625 ~ 632
Beuvinky, I / 2007 / A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs / Nucleic Acids Res 35 : 1 ~ 11
Brandt, O / 2003 / PNA microarrays for hybridisation of unlabelled DNA samples / Nucleic Acids Res 31 : e119 ~
Brandt, O / 2004 / Peptide nucleic acids on microarrays and other biosensors / Trends Biotechnol 22 : 617 ~ 622
Chiu, S.-K / 2003 / Synergistic effects of epoxy- and amine-silanes on microarray DNA immobilization and hybridization / Biochem. J 374 : 625 ~ 632
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