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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제12호
- 발행연도
- 2017.1
- 수록면
- 2,241 - 2,244 (4page)
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초록· 키워드
오류제보하기
The structure of concanavalin A (ConA) has been studied intensively owing to its specific interactions with carbohydrates and its heterometal (Ca2+ and Mn2+) coordination. Most structures from X-ray crystallography have shown ConA as a dimer or tetramer, because the complex formation requires specific crystallization conditions. Here, we reported the monomeric structure of ConA with a resolution of 1.6 Å, which revealed that metal coordination could trigger sugar-binding ability. The calcium coordination residue, Asn14, changed the orientation of carbohydrate-binding residues and biophysical details, including structural information, providing valuable clues for the development and application of detection kits using ConA.
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참고문헌 (21)
참고문헌 신청
Auer HE / 1984 / pH-dependent changes in properties of concanavalin A in the acid pH range / Int. J. Pept. Protein Res 24 : 462 ~ 471
Balzarini J. / 2007 / Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy / Nat. Rev. Microbiol 5 : 583 ~ 597
Bezerra GA / 2007 / Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of th
Bouckaert J / 2000 / The structural features of concanavalin A governing nonproline peptide isomerization / J. Biol. Chem 275 : 19778 ~ 19787
Bouckaert J / 2000 / Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing / Acta Crystallogr. D Biol. Crystallo
Balzarini J. / 2007 / Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy / Nat. Rev. Microbiol 5 : 583 ~ 597
Bezerra GA / 2007 / Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of th
Bouckaert J / 2000 / The structural features of concanavalin A governing nonproline peptide isomerization / J. Biol. Chem 275 : 19778 ~ 19787
Bouckaert J / 2000 / Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing / Acta Crystallogr. D Biol. Crystallo
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