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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제5호
- 발행연도
- 2017.1
- 수록면
- 933 - 938 (6page)
이용수
초록· 키워드
오류제보하기
Clitocybin A, an isoindolinone from Clitocybe aurantiaca, was investigated to assess its antiwrinkle properties, through reactive oxygen species (ROS)-scavenging and elastase inhibitory activities, procollagen synthesis, and matrix metalloproteinase-1 (MMP-1) expression, in human primary dermal fibroblast-neonatal (HDF-N) cells. Clitocybin A exhibited no significant cytotoxicity up to 10 ppm in HDF-N cells, with cell viability and cell proliferation activity greater than 94.6% and 91.9%, respectively. Strong and concentration-dependent ROS radical scavenging activities of clitocybin A were observed following irradiation with UVB at 30 mJ/cm2. Furthermore, clitocybin A treatment of cells at 0.1, 1, and 10 ppm exhibited decreased elastase activity, in a concentration-dependent manner, by 1.97%, 6.6%, and 8.31%, respectively, versus the control group. The effects of clitocybin A on procollagen synthesis and MMP-1 expression were investigated. Clitocybin A treatment of cells at 1, 5, and 10 ppm increased procollagen synthesis, by 67.9%, 74.4%, and 112.9%, respectively, versus the control group. At these concentrations, MMP-1 expression decreased significantly following UV irradiation. Together, these findings suggest that clitocybin A may be an effective ingredient for use in anti-wrinkle cosmetic products.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abe H / 2012 / UVB irradiation down-regulates type XVI collagen expression in mouse and human skin / J. Cosmet. Dermatol 11 : 169 ~ 178
Borg M / 2013 / The role of cytokines in skin aging / Climacteric 16 : 514 ~ 521
Burke EM / 1996 / Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors / Exp. Gerontol 29 : 37 ~ 53
Cevenini E / 2008 / Human models of aging and longevity / Expert Opin. Biol. Ther 8 : 1393 ~ 1405
Egbert M / 2014 / The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging / J. Dermatol. Sci 73 : 40 ~ 48
Borg M / 2013 / The role of cytokines in skin aging / Climacteric 16 : 514 ~ 521
Burke EM / 1996 / Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors / Exp. Gerontol 29 : 37 ~ 53
Cevenini E / 2008 / Human models of aging and longevity / Expert Opin. Biol. Ther 8 : 1393 ~ 1405
Egbert M / 2014 / The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging / J. Dermatol. Sci 73 : 40 ~ 48
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