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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제5호
- 발행연도
- 2017.1
- 수록면
- 1,010 - 1,022 (13page)
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Hybrid histidine kinase is part of a two-component system that is required for various stress responses and pathogenesis of pathogenic fungi. The Tco1 gene in human pathogen Cryptococcus neoformans encodes a hybrid histidine kinase and is important for pathogenesis.
In this study, we identified a Tco1 homolog, UmTco1, in the maize pathogen Ustilago maydis by bioinformatics analysis. To explore the role of UmTco1 in the survival of U. maydis under environmental stresses and its pathogenesis, Δumtco1 mutants were constructed by allelic exchange. The growth of Δumtco1 mutants was significantly impaired when they were cultured under hyperosmotic stress. The Δumtco1 mutants exhibited increased resistance to antifungal agent fludioxonil. In particular, the Δumtco1 mutants were unable to produce cytokinesis or conjugation tubes, and to develop fuzzy filaments, resulting in impaired mating between compatible strains. The expression levels of Prf1, Pra1, and Mfa1, which are involved in the pheromone pathway, were significantly decreased in the Δumtco1 mutants. In inoculation tests to the host plant, the Δumtco1 mutants showed significantly reduced ability in the production of anthocyanin pigments and tumor development on maize leaves. Overall, the combined results indicated that UmTco1 plays important roles in the survival under hyperosmotic stress, and contributes to cytokinesis, sexual development, and virulence of U.
maydis by regulating the expression of the genes involved in the pheromone pathway.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bahn YS / 2006 / A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans / Mol. Biol.
Buck V / 2001 / Peroxide sensors for the fission yeast stressactivated mitogen-activated protein kinase pathway / Mol. Biol. Cell 12 : 407 ~ 419
Catlett NL / 2003 / Whole-genome analysis of two-component signal transduction genes in fungal pathogens / Eukaryot. Cell 2 : 1151 ~ 1161
Davidson RC / 2002 / A PCR-based strategy to generate integrative targeting alleles with large regions of homology / Microbiology 148 : 2607 ~ 2615
Finn RD / 2016 / The Pfam protein families database:towards a more sustainable future / Nucleic Acids Res 44 : D279 ~ D285
Buck V / 2001 / Peroxide sensors for the fission yeast stressactivated mitogen-activated protein kinase pathway / Mol. Biol. Cell 12 : 407 ~ 419
Catlett NL / 2003 / Whole-genome analysis of two-component signal transduction genes in fungal pathogens / Eukaryot. Cell 2 : 1151 ~ 1161
Davidson RC / 2002 / A PCR-based strategy to generate integrative targeting alleles with large regions of homology / Microbiology 148 : 2607 ~ 2615
Finn RD / 2016 / The Pfam protein families database:towards a more sustainable future / Nucleic Acids Res 44 : D279 ~ D285
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