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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제5호
- 발행연도
- 2017.1
- 수록면
- 975 - 982 (8page)
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초록· 키워드
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Curcumin, a hydrophobic polyphenol derived from the rhizome of the herb Curcuma longa, possesses diverse pharmacological properties, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Two curcuminoids (dicinnamoylmethane and bisdemethoxycurcumin) were synthesized from glucose in Escherichia coli. PAL (phenylalanine ammonia lyase) or TAL (tyrosine ammonia lyase), along with Os4CL (p-coumaroyl-CoA ligase) and CUS (curcumin synthase) genes, were introduced into E. coli, and each strain produced dicinnamoylmethane or bisdemethoxycurcumin, respectively. In order to increase the production of curcuminoids in E. coli, the shikimic acid biosynthesis pathway, which increases the substrates for curcuminoid biosynthesis, was engineered. Using the engineered strains, the production of bisdemethoxycurcumin increased from 0.32 to 4.63 mg/l, and that of dicinnamoylmethane from 1.24 to 6.95 mg/l.
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참고문헌 (24)
참고문헌 신청
Aggarwal BB / 2008 / Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets / Trends Pharm. Sci 30 : 85 ~ 94
Austin MB / 2003 / The chalcone synthase superfamily of type III polyketide synthases / Nat. Prod. Rep 20 : 79 ~ 110
Cochrane FC / 2004 / The Arabidopsis phenylalanine ammonia lyase
Flores-Sanchez IJ / 2009 / Plant polyketide synthase: a fascinating group of enzymes / Plant Physiol. Biochem 47 : 167 ~ 174
Howitz KT / 2003 / Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan / Nature 425 : 191 ~ 196
Austin MB / 2003 / The chalcone synthase superfamily of type III polyketide synthases / Nat. Prod. Rep 20 : 79 ~ 110
Cochrane FC / 2004 / The Arabidopsis phenylalanine ammonia lyase
Flores-Sanchez IJ / 2009 / Plant polyketide synthase: a fascinating group of enzymes / Plant Physiol. Biochem 47 : 167 ~ 174
Howitz KT / 2003 / Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan / Nature 425 : 191 ~ 196
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