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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제11호
- 발행연도
- 2010.1
- 수록면
- 1,484 - 1,490 (7page)
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초록· 키워드
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In the Streptomyces hygroscopicus JCM4427 geldanamycin biosynthetic gene cluster, five putative regulatory genes were identified by protein homology searching. Among those genes, gel14, gel17, and gel19 are located downstream of polyketide synthase genes. Gel14 and Gel17 are members of the LAL family of transcriptional regulators,including an ATP/GTP-binding domain at the N-terminus and a DNA-binding helix-turn-helix domain at the Cterminus.
Gel19 is a member of the TetR family of transcriptional regulators, which generally act to repress transcription. To verify the biological significance of the putative regulators in geldanamycin production, they were individually characterized by gene disruption, genetic complementation, and transcriptional analyses. All three genes were confirmed as positive regulators of geldanamycin production. Specifically, Gel17 and Gel19 are required for gel14 as well as gelA gene expression.
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참고문헌 (24)
참고문헌 신청
Ahn, S. K / 2007 / Investigation of transcription repression and small-molecule responsiveness by TetR-like transcription factors using a heterologous Escherichia coli-based
Bibb, M. J / 2005 / Regulation of secondary metabolism in streptomycetes / Curr. Opin. Microbiol 8 : 208 ~ 215
Bierman, M / 1992 / Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp / Gene 116 : 43 ~ 49
De Schrijver, A / 1999 / A subfamily of MalTrelated ATP-dependent regulators in the LuxR family / Microbiology 145 : 1287 ~ 1288
Denis, F / 1991 / An improved aminoglycoside resistance gene cassette for use in Gram-negative bacteria and Streptomyces / FEMS Microbiol. Lett 81 : 261 ~ 264
Bibb, M. J / 2005 / Regulation of secondary metabolism in streptomycetes / Curr. Opin. Microbiol 8 : 208 ~ 215
Bierman, M / 1992 / Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp / Gene 116 : 43 ~ 49
De Schrijver, A / 1999 / A subfamily of MalTrelated ATP-dependent regulators in the LuxR family / Microbiology 145 : 1287 ~ 1288
Denis, F / 1991 / An improved aminoglycoside resistance gene cassette for use in Gram-negative bacteria and Streptomyces / FEMS Microbiol. Lett 81 : 261 ~ 264
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