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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제4호
- 발행연도
- 2015.1
- 수록면
- 439 - 447 (9page)
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초록· 키워드
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The objective of this study was to isolate and identify the chemical structure of a biosurfactant produced by Nocardia farcinica strain BN26 isolated from soil, and evaluate its in vitro antitumor activity on a panel of human cancer cell lines. Strain BN26 was found to produce glycolipid biosurfactant on n-hexadecane as the sole carbon source. The biosurfactant was purified using medium-pressure liquid chromatography and characterized as trehalose lipid tetraester (THL) by nuclear magnetic resonance spectroscopy and mass spectrometry. Subsequently, the cytotoxic effects of THL on cancer cell lines BV-173, KE-37 (SKW-3), HL-60, HL-60/DOX, and JMSU-1 were evaluated by MTT assay. It was shown that THL exerted concentration-dependent antiproliferative activity against the human tumor cell lines and mediated cell death by the induction of partial oligonucleosomal DNA fragmentation. These findings suggest that THL could be of potential to apply in biomedicine as a therapeutic agent.
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참고문헌 (23)
참고문헌 신청
B endinger B / 1993 / Physicochemical cell surface and adhesive properties of coryneform bacteria related to the presence and chain length of mycolic acids / Appl. Environ. M
B ouchez-Naitali M / 2001 / Evidence for interfacial uptake in hexadecane degradation by Rhodococcus equi: the importance of cell flocculation / Microbiology 147 : 2537 ~ 254
Desai JD / 1997 / Microbial production of surfactants and their commercial potential / Microbiol. Mol. Biol. Rev 61 : 47 ~ 64
E spuny MJ / 1995 / Characterization of trehalose tetraester produced by a waste lubricant oil degrader Rhodococcus sp / Toxicol. Environ 48 : 83 ~ 88
F ranzetti A / 2008 / Surface-active compounds and their role in the access to hydrocarbons in Gordonia strains / FEMS Microbiol. Ecol 63 : 238 ~ 248
B ouchez-Naitali M / 2001 / Evidence for interfacial uptake in hexadecane degradation by Rhodococcus equi: the importance of cell flocculation / Microbiology 147 : 2537 ~ 254
Desai JD / 1997 / Microbial production of surfactants and their commercial potential / Microbiol. Mol. Biol. Rev 61 : 47 ~ 64
E spuny MJ / 1995 / Characterization of trehalose tetraester produced by a waste lubricant oil degrader Rhodococcus sp / Toxicol. Environ 48 : 83 ~ 88
F ranzetti A / 2008 / Surface-active compounds and their role in the access to hydrocarbons in Gordonia strains / FEMS Microbiol. Ecol 63 : 238 ~ 248
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