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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제11호
- 발행연도
- 2018.1
- 수록면
- 1,876 - 1,882 (7page)
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초록· 키워드
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A series of pentacyclic triterpenoids similar to glycyrrhetinic acid were designed and synthesized via the combination of chemical modification and microbial catalysis. All products were screened for the glycogen phosphorylases inhibitory activities in vitro. Within this series of derivatives, compound 5 displayed good inhibitory activities with IC50 value of 27.7 μM, which is better than that of the other derivatives and glycyrrhetinic acid. Structure– activity relationship (SAR) analysis of these inhibitors was also discussed.
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참고문헌 (22)
참고문헌 신청
Armanini D / 2002 / History of the endocrine effects of licorice / Exp. Clin. Endocrinol. Diabetes 110:257~261
Shibata S. / 2000 / A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice / Yakugaku Zasshi 120:849~862
René C / 2010 / Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid / Eur. J. Med. Chem 45:5718~5723
Mauro S / 2003 / Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria / Biochem. Pharmacol 66:2375~2379
Matsui S / 2004 / Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8and eotaxin 1 in a human lung fibroblast cell line / Int. Immunopharmacol 15:1633~1644
Shibata S. / 2000 / A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice / Yakugaku Zasshi 120:849~862
René C / 2010 / Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid / Eur. J. Med. Chem 45:5718~5723
Mauro S / 2003 / Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria / Biochem. Pharmacol 66:2375~2379
Matsui S / 2004 / Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8and eotaxin 1 in a human lung fibroblast cell line / Int. Immunopharmacol 15:1633~1644
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