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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제11호
- 발행연도
- 2016.1
- 수록면
- 1,972 - 1,982 (11page)
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Influenza A virus is a single-stranded RNA virus with a genome of negative polarity. Owing to the antigenic diversity and cross concrete shift, an immense number of novel strains have developed astronomically over the years. The present work deals with the codon utilization partialness among five different influenza A viruses isolated from human hosts. All the subtypes showed the homogeneous pattern of nucleotide utilization with a little variation in their utilization frequencies. A lower bias in codon utilization was observed in all the subtypes as reflected by higher magnitudes of an efficacious number of codons. Dinucleotide analysis showed very low CpG utilization and a high predilection of A/T-ending codons. The H5N1 subtype showed noticeable deviation from the rest. Codon pair context analysis showed remarkable depletion of NNC-GNN and NNT-ANN contexts. The findings alluded towards GC-compositional partialness playing a vital role, which is reflected in the consequential positive correlation between the GC contents at different codon positions. Untangling the codon utilization profile would significantly contribute to identifying novel drug targets that will pacify the search for antivirals against this virus.
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참고문헌 (39)
참고문헌 신청
안인성 / 2010 / Comparative Study of the Nucleotide Bias Between the Novel H1N1 and H5N1 Subtypes of Influenza A Viruses Using Bioinformatics Techniques / Journal of Microbiology and Biotechnology 20(1):63~70
Akashi H / 1994 / Synonymous codon usage in Drosophila melanogaster: natural selection and translational accuracy / Genetics 136:927~935
Boycheva S / 2003 / Codon pairs in the genome of Escherichia coli / Bioinformatics 19:987~998
Chen Y / 2013 / A comparison of synonymous codon usage bias patterns in DNA and RNA virus genomes: quantifying the relative importance of mutational pressure and natural selection / Biomed. Res. Int 2013:406342
Cheng X / 2013 / CpG usage in RNA viruses: data and hypotheses / PLoS One 8:e74109
Akashi H / 1994 / Synonymous codon usage in Drosophila melanogaster: natural selection and translational accuracy / Genetics 136:927~935
Boycheva S / 2003 / Codon pairs in the genome of Escherichia coli / Bioinformatics 19:987~998
Chen Y / 2013 / A comparison of synonymous codon usage bias patterns in DNA and RNA virus genomes: quantifying the relative importance of mutational pressure and natural selection / Biomed. Res. Int 2013:406342
Cheng X / 2013 / CpG usage in RNA viruses: data and hypotheses / PLoS One 8:e74109
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