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논문 기본 정보
- 자료유형
- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제12호
- 발행연도
- 2010.1
- 수록면
- 1,769 - 1,771 (3page)
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초록· 키워드
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The envelope glycoprotein E2 of hepatitis C virus (HCV)binds to various cell surface receptors for viral infection.
We performed biopanning against this protein and selected peptides from phage display peptide libraries.
Two short peptides, pep7-1 and pep12-1, were selected and their ability to inhibit the infection process was investigated. When pep7-1 was present, the infectivity of HCV particles in cell culture was notably decreased. This decrease was demonstrated by Western blot analysis,immunofluorescence assay, and reverse transcription PCR assay. However, pep12-1 showed little inhibitory effect on HCV infection.
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참고문헌 (15)
참고문헌 신청
Benedicto, I / 2009 / The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection / J. Virol 83 : 8012 ~ 8020
Blanchard, E / 2006 / Hepatitis C virus entry depends on clathrin-mediated endocytosis / J. Virol 80 : 6964 ~ 6972
Evans, M. J / 2007 / Claudin-1 is a hepatitis C virus coreceptor required for a late step in entry / Nature 446 : 801 ~ 805
Helle, F / 2008 / Hepatitis C virus entry into host cells / Cell Mol. Life Sci 65 : 100 ~ 112
Higginbottom, A / 2000 / Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2 / J. Virol 74 : 3642 ~ 3649
Blanchard, E / 2006 / Hepatitis C virus entry depends on clathrin-mediated endocytosis / J. Virol 80 : 6964 ~ 6972
Evans, M. J / 2007 / Claudin-1 is a hepatitis C virus coreceptor required for a late step in entry / Nature 446 : 801 ~ 805
Helle, F / 2008 / Hepatitis C virus entry into host cells / Cell Mol. Life Sci 65 : 100 ~ 112
Higginbottom, A / 2000 / Identification of amino acid residues in CD81 critical for interaction with hepatitis C virus envelope glycoprotein E2 / J. Virol 74 : 3642 ~ 3649
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