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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제4호
- 발행연도
- 2012.1
- 수록면
- 494 - 500 (7page)
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초록· 키워드
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Silk fibroin (SF) peptide has been traditionally used as a treatment for flatulence, spasms, and phlegm. In this study,we examined whether SF peptide enhanced the antiinflammatory effect of PEP-1-FK506 binding protein (PEP-1-FK506BP) through comparing the anti-inflammatory activities of SF peptide and/or PEP-1-FK506BP. In the presence or absence of SF peptide, transduction levels of PEP-1-FK506BP into HaCaT cells and mice skin and anti-inflammatory activities of PEP-1-FK506BP were identified by Western blot and histological analyses. SF peptide alone effectively reduced both mice ear edema and the elevated levels of cyclooxygenase-2, interleukin-6and -1β, and tumor necrosis factor-α, showing similar anti-inflammatory effect to that of PEP-1-FK506BP.
Furthermore, co-treatment with SF peptide and PEP-1-FK506BP exhibited more enhanced anti-inflammatory effects than the samples treated with SF peptides or PEP-1-FK506BP alone, suggesting the possibility that SF peptide and PEP-1-FK506BP might interact with each other. Moreover, the transduction data demonstrated that SF peptide did not affect the transduction of PEP-1-FK506BP into HaCaT cells and mice skin, indicating that the improvement of anti-inflammatory effect of PEP-1-FK506BP was not caused by enhanced transduction of PEP-1-FK506BP. Thus, these results suggest the possibility that co-treatment with SF peptide and PEP-1-FK506BP may be exploited as a useful therapy for various inflammationrelated diseases.
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참고문헌 (24)
참고문헌 신청
Bickers, D. R. / 2006 / Oxidative stress in the pathogenesis of skin disease / J. Invest. Dermatol 126 : 2565 ~ 2575
Breiman, A. / 2002 / The involvement of mammalian and plant FK506-binding proteins (FKBPs) in development / Transgenic Res 11 : 321 ~ 335
Dietz, G. P. / 2010 / Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research / Curr. Pharm. Biotechol 11 : 167 ~ 174
Dunlop, E. A. / 2009 / Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms / Cell Signal 21 : 827 ~ 835
Floyd, R. A. / 1990 / Role of oxygen free radicals in carcinogenesis and brain ischemia / FASEB J 4 : 2587 ~ 2597
Breiman, A. / 2002 / The involvement of mammalian and plant FK506-binding proteins (FKBPs) in development / Transgenic Res 11 : 321 ~ 335
Dietz, G. P. / 2010 / Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research / Curr. Pharm. Biotechol 11 : 167 ~ 174
Dunlop, E. A. / 2009 / Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms / Cell Signal 21 : 827 ~ 835
Floyd, R. A. / 1990 / Role of oxygen free radicals in carcinogenesis and brain ischemia / FASEB J 4 : 2587 ~ 2597
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