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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제10호
- 발행연도
- 2009.1
- 수록면
- 1,109 - 1,121 (13page)
이용수
초록· 키워드
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In an attempt to discover novel biomarker proteins in
type 2 diabetes prognosis, we investigated the influence of
hypoglycemic extracellular polysaccharides (EPS) obtained
from the macrofungus Tremella fuciformis on the differential
levels of plasma proteins in ob/ob mice using two-dimensional
gel electrophoresis (2-DE). The 2-DE analysis demonstrated
that 92 spots from about 900 visualized spots were
differentially regulated, of which 40 spots were identified
as principal diabetes-associated proteins. By comparing
control with EPS-fed mice, we found that at least six
proteins were significantly altered in ob/ob mice, including
Apo A-I, IV, C-III, E, retinol-binding protein 4, and
transferrin, and their levels were interestingly normalized
after EPS treatment. Western blot analysis revealed that
the altered levels of the two regulatory molecules highlighted
in diabetes and obesity (e.g., resistin and adiponectin) were
also normalized in response to EPS. The Mouse Diabetes
PCR Array profiles showed that the expression of 84 genes
related to the onset, development, and progression of
diabetes were significantly downregulated in liver, adipocyte,
and muscle of ob/ob mice. EPS might act as a potent
regulator of gene expression for a wide variety of genes in
ob/ob mice, particularly in obesity, insulin resistance, and
complications from diabetes mellitus.
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참고문헌 (22)
참고문헌 신청
Bowers, R. R. / 2006 / Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene / Proc. Natl. Acad. Sci. U.S.A. 103 : 130
Bradford, M. M. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 7
Cho, E. J. / 2006 / Production of exopolysaccharides by submerged mycelial culture of a mushroom Tremella fuciformis / J. Biotechnol 127 : 129 ~ 140
Cho, E. J. / 2007 / Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice
Curtiss, L. K. / 2000 / Apolipoprotein E and atherosclerosis / Curr. Opin. Lipidol 11 : 243 ~ 251
Bradford, M. M. / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 7
Cho, E. J. / 2006 / Production of exopolysaccharides by submerged mycelial culture of a mushroom Tremella fuciformis / J. Biotechnol 127 : 129 ~ 140
Cho, E. J. / 2007 / Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice
Curtiss, L. K. / 2000 / Apolipoprotein E and atherosclerosis / Curr. Opin. Lipidol 11 : 243 ~ 251
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