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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 154 - 160 (7page)
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초록· 키워드
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BACKGROUND/OBJECTIVE: We examined the hypoglycemic and anti-hyperlipidemic effect of yeast hydrolysate (YH) enriched with Cyclo-His-Pro (CHP) in the C57BL/6J ob/ob mouse model.
MATERIALS/METHODS: Mice were separated into 4 groups (8 mice/group) on the basis of blood glucose and body weight: WT control, lean mice given vehicle; ob/ob control, ob/ob mice given vehicle; YH-1, ob/ob mice given 0.5 g/㎏ of YH; YH-2, ob/ob mice given 1 g/㎏ of YH. YH in saline or vehicle was administered orally in the same volume every day for 3 weeks.
RESULTS: Mice treated with YH (0.5 and 1 g/㎏) for 3 weeks displayed a significant reduction in overall body weight gain and perirenal and epididymal adipose tissue weight compared to the ob/ob control group. Additionally, high-density lipoprotein (HDL) cholesterol, glucose, and atherogenic indexes were significantly decreased in the blood of YH-1 and YH-2 groups compared to the ob/ob control. In ob/ob mice, YH administration significantly improved glucose tolerance and blood insulin levels. These data indicate that YH treatment produces potent hypoglycemic and anti-hyperlipidemic effects by controlling body weight, fat mass, blood lipid, insulin levels, and glucose tolerance.
CONCLUSION: YH could potentially be used as a treatment option for diabetes and hyperlipidemia. The CHP-enriched YH may be a promising strategy in the development of hypoglycemic peptide nutraceuticals.
MATERIALS/METHODS: Mice were separated into 4 groups (8 mice/group) on the basis of blood glucose and body weight: WT control, lean mice given vehicle; ob/ob control, ob/ob mice given vehicle; YH-1, ob/ob mice given 0.5 g/㎏ of YH; YH-2, ob/ob mice given 1 g/㎏ of YH. YH in saline or vehicle was administered orally in the same volume every day for 3 weeks.
RESULTS: Mice treated with YH (0.5 and 1 g/㎏) for 3 weeks displayed a significant reduction in overall body weight gain and perirenal and epididymal adipose tissue weight compared to the ob/ob control group. Additionally, high-density lipoprotein (HDL) cholesterol, glucose, and atherogenic indexes were significantly decreased in the blood of YH-1 and YH-2 groups compared to the ob/ob control. In ob/ob mice, YH administration significantly improved glucose tolerance and blood insulin levels. These data indicate that YH treatment produces potent hypoglycemic and anti-hyperlipidemic effects by controlling body weight, fat mass, blood lipid, insulin levels, and glucose tolerance.
CONCLUSION: YH could potentially be used as a treatment option for diabetes and hyperlipidemia. The CHP-enriched YH may be a promising strategy in the development of hypoglycemic peptide nutraceuticals.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (42)
참고문헌 신청
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Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence ofdiabetes: estimates for the year 2000 and projections for 2030.Diabetes Care 2004;27:2568-9.
Goldfrank L, Lewin N, Flomenbaum N, Howland MA. The perniciouspanacea: herbal medicine. Hosp Physician 1982;18:64-9.
Sabu MC, Smitha K, Kuttan R. Anti-diabetic activity of green teapolyphenols and their role in reducing oxidative stress inexperimental diabetes. J Ethnopharmacol 2002;83:109-16.
Pari L, Umamaheswari J. Antihyperglycaemic activity of Musa sapientumflowers: effect on lipid peroxidation in alloxan diabetic rats. PhytotherRes 2000;14:136-8.
Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence ofdiabetes: estimates for the year 2000 and projections for 2030.Diabetes Care 2004;27:2568-9.
Goldfrank L, Lewin N, Flomenbaum N, Howland MA. The perniciouspanacea: herbal medicine. Hosp Physician 1982;18:64-9.
Sabu MC, Smitha K, Kuttan R. Anti-diabetic activity of green teapolyphenols and their role in reducing oxidative stress inexperimental diabetes. J Ethnopharmacol 2002;83:109-16.
Pari L, Umamaheswari J. Antihyperglycaemic activity of Musa sapientumflowers: effect on lipid peroxidation in alloxan diabetic rats. PhytotherRes 2000;14:136-8.
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UCI(KEPA) : I410-ECN-0101-2016-594-002541979