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Suppression of Metastasis of Human Breast Cancer Cells by Chitosan Oligosaccharides
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논문 기본 정보

Type
Academic journal
Author
Journal
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제6호 KCI Accredited Journals SCOPUS
Published
2009.1
Pages
629 - 633 (5page)

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Suppression of Metastasis of Human Breast Cancer Cells by Chitosan Oligosaccharides
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Abstract· Keywords

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The present study investigated the antimetastatic property of chitosan oligosaccharides (COS) by evaluating motility, invasion, and the amount and activity of MMP-9 in MDA-MB-231 human breast carcinoma cells. Treatment of MDA-MB-231 cells with increasing concentrations of COS led to a concentration-dependent decrease in cell migration. COS significantly inhibited the invasion of MDA-MB-231 cells through a Matrigel-coated membrane. The treatment of MDA-MB-231 cells with COS reduced the amounts of secreted MMP-9. The activity and amount of MMP-9 protein in MDA-MB-231 cells were decreased by treatment with COS and occurred in a concentrationdependent manner. Our data indicated that COS can serve as a potential novel therapeutic candidate for the treatment of metastatic breast cancer.
#Breast cancer #chitosan oligosaccharides #invasion #metastasis #matrix metalloproteinase

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References (20)

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Aye, M. M. / 2004 / Ethanol-induced in vitro invasion of breast cancer cells: The contribution of MMP-2 by fibroblasts / Int. J. Cancer 112 : 738 ~ 746 google schola Bachmeier, B. E. / 2001 / Matrix metalloproteinases (MMPs) in breast cancer cell lines of different tumorigenicity / Anticancer Res 21 : 3821 ~ 3828 google schola Chen, J. / 2003 / Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro / Breast Cancer Res. Treat 80 : 16 google schola Cho, Eun Jae / 2008 / Chitosan Oligosaccharides Inhibit Adipogenesis in 3T3-L1 Adipocytes / Journal of Microbiology and Biotechnology 18 (1) : 80 ~ 87 google schola Friedel, G. / 2002 / Results of lung metastasectomy from breast cancer: Prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases / Eur. google schola

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