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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제5호
- 발행연도
- 2008.1
- 수록면
- 975 - 982 (8page)
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초록· 키워드
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We investigated whether transplantation of osteogenically differentiated bone marrow-derived mesenchymal stem cells (BMMSCs) and the use of an hydroxyapatite (HAp) scaffold can enhance the in vivo bone formation efficacy of human BMMSCs. Three months after implantation to the subcutaneous dorsum of athymic mice, transplantation of osteogenically differentiated human BMMSCs increased the bone formation area and calcium deposition to 7.1- and 6.2-folds, respectively, of those of transplantation of undifferentiated BMMSCs. The use of the HAp scaffold increased the bone formation area and calcium deposition to 3.7- and 3.5-folds, respectively, of those of a polymer scaffold. Moreover, a combination of transplantation of osteogenically differentiated BMMSCs and HAp scaffold further increased the bone formation area and calcium deposition to 10.6- and 9.3-folds, respectively, of those of transplantation of undifferentiated BMMSCs seeded onto polymer scaffolds. The factorial experimental analysis showed that osteogenic differentiation of BMMSCs prior to transplantation has a stronger positive effect than the HAp scaffold on in vivo bone formation.
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참고문헌 (23)
참고문헌 신청
Arinzeh, T. L. / 2003 / Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect. J. Bone Joint Surg / Am 85 : 1927 ~ 1935
Attin, T. / 2005 / Method to detect minimal amounts of calcium dissolved in acidic solutions / Caries Res 39 : 432 ~ 436
Bruder, S. P. / 1998 / The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J. Bone Joint Surg / Am 80 : 985
Chen, Y. L. / 2006 / Rational development of GAG-augmented chitosan membranes by fractional factorial design methodology / Biomaterials 27 : 2222 ~ 2232
Cheng, S. L. / 1994 / Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone / Endocrinology 134 : 277
Attin, T. / 2005 / Method to detect minimal amounts of calcium dissolved in acidic solutions / Caries Res 39 : 432 ~ 436
Bruder, S. P. / 1998 / The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J. Bone Joint Surg / Am 80 : 985
Chen, Y. L. / 2006 / Rational development of GAG-augmented chitosan membranes by fractional factorial design methodology / Biomaterials 27 : 2222 ~ 2232
Cheng, S. L. / 1994 / Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone / Endocrinology 134 : 277
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