지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제4호
- 발행연도
- 2005.1
- 수록면
- 895 - 898 (4page)
이용수
초록· 키워드
오류제보하기
In the course of searching for potent chitinsynthase 1 inhibitors from natural resources, Streptomyces sp.A6705 was found to exhibit potent inhibitory activity againstthe chitin synthase 1 from C. albicans (CaCHS1p). As aresult, the inhibitor was isolated and identified using aseries of chromatographies. Through chemical analyses withUV spectrophotometry, MS spectrometry, and various NMRtechniques, the inhibitor was identified as N,N-bis(2-phenylethyl)urea. The compound exhibited strong inhibitoryactivity against the chitin synthase 1 from C. albicans with anIC50 of 14 μg/ml, representing a similar inhibitory activityto that of the well-known chitin synthase inhibitor, polyoxinD (IC50 15 μg/ml). However, the compound showed noinhibitory activity against the chitin synthase 2 of Saccharomycescerevisiae up to 280 μg/ml, which is structurally and functionallyanalogous to CaCHS1p. In addition, the compound exhibitedweak antifungal activities against Cryptococcus neoformansand Rhizoctonis solani.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
/ 1987 / Two chitin synthases in Saccharomycescerevisiae : 5732 ~ 5739
/ 1993 / Genetics and molecular biology ofchitin synthesis in fungi : 505 ~ 534
A / 1978 / 3-Diphenethylurea from Streptomyces sp : 375 ~ 2498 376
Chiou / 2000 / New drugsand novel targets for treatment of invasive fungal infectionsin patients with cancer 5 : 120 ~ 5 135
Choi / 1998 / The determination of chitin synthases byvarying pH and divalent cations in Candida albicans 8 : 613 ~ 617
/ 1993 / Genetics and molecular biology ofchitin synthesis in fungi : 505 ~ 534
A / 1978 / 3-Diphenethylurea from Streptomyces sp : 375 ~ 2498 376
Chiou / 2000 / New drugsand novel targets for treatment of invasive fungal infectionsin patients with cancer 5 : 120 ~ 5 135
Choi / 1998 / The determination of chitin synthases byvarying pH and divalent cations in Candida albicans 8 : 613 ~ 617
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Determination of Chitin synthases by varying pH and Divalent Cations in Candida albicans
한국동물학회 학술대회
1998 .01
-
Identification of a Domain in Yeast Chitin Synthase 3 Required for Biogenesis of Chitin Ring, But Not Cellular Chitin Synthesis
한국미생물학회 학술대회논문집
2000 .10
-
Differential Inhibition of chitin synthases isozymes in Candida albicans by Polyoxin D and Nikkomycin Z.
한국동물학회 학술대회
1998 .01
-
The Putative Inhibitors of V-ATPase in Candida albicans and Its Antifungal Activity
한국미생물학회 학술대회논문집
2013 .05
-
Regulation of chitin synthase 3 of Saccharomyces cerevisiae in the vegetative cell cycle
한국동물학회 학술대회
1998 .01
-
Cell Cycle-dependent Expression of Chitin Synthase Genes in Aspergillus nidulans
The Journal of Microbiology
2001 .03
-
Antifungal Activity of Salvia miltiorrhiza Against Candida albicans Is Associated with the Alteration of Membrane Permeability and (1,3)-β-D-Glucan Synthase Activity
Journal of Microbiology and Biotechnology
2016 .01
-
Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitor Isolated from Newly Screened Streptomyces Strain
한국미생물학회 학술대회논문집
2011 .05
-
Phylogenetic Study of Penicillium chrysogenum Based on the Amino Acid Sequence Analysis of Chitin Synthase
The Journal of Microbiology
1997 .09
-
키틴을 이용한 폴리(L-젖산)(Poly(L-lactic acid)(PLLA)) 전기방사 나노섬유의 기계적 보강
한국해양바이오학회지
2019 .12
-
Phylogenetic Study of the Hemiascomycetous Yeasts Based on Chitin Synthase Genes
한국동물학회 학술대회
1999 .01
-
Genomic Organization of Penicillium chrysogenum chs4, a Class III Chitin Synthase Gene
The Journal of Microbiology
2000 .12
-
Extract of Streptomyces sp. R301 as a Highly Potent Tyrosinase Inhibitor
한국미생물학회 학술대회논문집
2019 .04
-
인정장이 Candida albicans 감염에 미치는 영향
The Journal of the Korean Society for Microbiology
1988 .06
-
A CoMFA Study of Glycogen Synthase Kinase 3 Inhibitors
조선자연과학논문집
2015 .01
-
Diesel Exhaust Particles and Airway Inflammation: Effect of Nitric Oxide Synthase Inhibitors
한국대기환경학회지(영문)
2002 .06
-
Compound IKD-8344, a Selective Growth Inhibitor Against the MycelialForm of Candida albicans, Isolated from Streptomyces sp. A6792
Journal of Microbiology and Biotechnology
2005 .01
-
Cloning and Phylogenetic Analysis of Chitin Synthase Genes from Tricholoma matsutake
Mycobiology
2001 .01
-
Cloning and Phylogenetic Analysis of Chitin Synthase Gene from Entomopathogenic Fungus, Beauveria brongniartii
The Journal of Microbiology
1997 .09
-
Rapid PCR Method for Detecting Candida albicans Using Primers Derived from the Integrin-like Protein Gene αINT1 of Candida albicans
The Journal of Microbiology
2000 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0