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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제4호
- 발행연도
- 2005.1
- 수록면
- 767 - 771 (5page)
이용수
초록· 키워드
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Expression in yeast may prove more amenable togenerating large amounts of viral antigens for a vaccinecandidate. We, therefore, cloned the gene encoding theHepatitis C virus (HCV) structural proteins (C-E1-E2, c740)fused in-frame with, and immediately 3' to, the chickenlysozymesignal peptide (C-SIG) gene and under the controlof the yeast glyceraldehyde-3-phosphate dehydrogenase genepromoter. In yeast, the HCV structural proteins were expressedin two different forms: a processed and a nonprocessedaggregated form. Biophysical characterization by sucroselinear gradient centrifugation revealed that both forms werepresent in the same fractions with a buoyant density of1.127-1.176 g/cm3. These findings suggest that the efficientsynthesis of HCV structural proteins in yeast may be animportant tool to study virus assembly and may lead to thedevelopment of an HCV vaccine.
목차
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참고문헌 (14)
참고문헌 신청
A / 1993 / Expression and identification of hepatitisC virus polyprotein cleavage products : 1385 ~ 1395
A / 1999 / Characterization ofaggregates of hepatitis C virus glycoproteins 80 : 3099 ~ 3107
Baumert / 1999 / Hepatitis C virus-like particles synthesized ininsect cells as a potential vaccine candidate : 1397 ~ 1407
Clayton / 2002 / Analysis of antigenicity and topologyof E2 glycoprotein present on recombinant hepatitis C viruslikeparticles 76 : 7672 ~ 7682
Dubuisson / 1999 / assembly and subcellularlocalization of HCV glcoproteins immu (l) : 135 ~ 148
A / 1999 / Characterization ofaggregates of hepatitis C virus glycoproteins 80 : 3099 ~ 3107
Baumert / 1999 / Hepatitis C virus-like particles synthesized ininsect cells as a potential vaccine candidate : 1397 ~ 1407
Clayton / 2002 / Analysis of antigenicity and topologyof E2 glycoprotein present on recombinant hepatitis C viruslikeparticles 76 : 7672 ~ 7682
Dubuisson / 1999 / assembly and subcellularlocalization of HCV glcoproteins immu (l) : 135 ~ 148
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