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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 588 - 593 (6page)
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초록· 키워드
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Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are cytopathic to liver, three types of transgenic m ice were established.
The expression of transgenes was confirmed by HCV specific RT-PCR and Western immunoblotting. The livers of all wild type core and S116I transgenic lineages remained largely histologically normal. However, the livers of the S99Q transgenic mice showed significant high level of cell dysplasia associated with the transgene expression in hepatocytes largely located around the central veins by in situ hybridization analysis. In conclusion, the mutant HCV core protein at S99Q may contribute to the progress of HCV induced liver disease.
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참고문헌 (24)
참고문헌 신청
/ / Dissecting multistep tumorigenesis in transgenicmice : 479 ~ 519
/ / Hepatitis C virus infection is associated with the developmentof hepatocellular carcinoma : 6547 ~ 9
/ / Morphologic studies of the livercell dysplasia : 2197 ~ 205
/ 1995 / Characteristic difference of hepatocellular carcinoma betweenhepatitis B- and C-viral infection in Japan : 1027 ~ 33
/ 1995 / Differentialsubcellular localization of hepatitis C virus core geneproducts : 455 ~ 61
/ / Hepatitis C virus infection is associated with the developmentof hepatocellular carcinoma : 6547 ~ 9
/ / Morphologic studies of the livercell dysplasia : 2197 ~ 205
/ 1995 / Characteristic difference of hepatocellular carcinoma betweenhepatitis B- and C-viral infection in Japan : 1027 ~ 33
/ 1995 / Differentialsubcellular localization of hepatitis C virus core geneproducts : 455 ~ 61
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